Clustered Cells in Intervertebral Discs Are Not More Viable Sources for Regenerative Therapies Than Single Cells, Nanofibrous Scaffolds Help Regenerate Nucleus Pulposus in Intervertebral Discs, Implanted Synovial Mesenchymal Stem Cells Prevent Intervertebral Disc Degeneration in Rabbit Model, Current Concepts in the Diagnosis and Treatment of Lumbar Degenerative Disc Disease, Systematic Review Confirms Safety and Efficacy of Mesenchymal Stem Cells in Treating Disc Degeneration, Hydrogels made of ionically crosslinked metacrylated gellan gum hydrogels (iGG-MA), Hydrogels made of iGG-MA functionalized with non-cytotoxic polylysine-based vascular endothelial growth factor blockers (VEGF-blockers), Hydrogels made of dodecyl-amide of hyaluronic acid (DDAHA), Hydrogels made of DDAHA and seeded with autologous BMC. Injectable hydrogel has the potential to be an appropriate cell scaffold as it can mimic the condition of the natural extracellular matrix (ECM) of nucleus pulposus (NP) and provide binding sites for cells. Intervertebral disc (IVD) degeneration has been implicated as a major component of spine pathology. In the present study, the regenerative potential of an autologous nucleus pulposus (NP)-cell-seeded thermoresponsive hyaluronic acid hydrogel in human lumbar IVDs was assessed under physiological conditions. 2 The Stimulation of Healing of the Anterior Cruciate Ligament: Research and Clinical Relevance Introduction: In this study, two types of hydrogels for nucleus replacement were investigated in an ovine nucleotomy model: 1) hydrogels functionalized with anti-angiogenic peptides, and 2) seeded with bone marrow derived mononuclear cells (BMC). This page is best viewed with JavaScript enabled. Journal Article. intervertebral disc (IVD) degeneration. Hydrogels in acellular and cellular strategies for intervertebral disc regeneration DR Pereira1,2*, J Silva-Correia1,2, JM Oliveira1,2 and RL Reis1,2 13B’s Research Group – Biomaterials, Biodegradables and Biomimetics, Univ. With the achievement of CNF-filled CHI hydrogels, biomaterial-based implants were designed to restore damaged/degenerated discs. This study demonstrates the potential of new injectable chitosan hydrogels formulations with interesting mechanical properties for the regeneration of intervertebral discs, in particular their central part called nucleus pulposus (NP). Suppression of adverse angiogenesis in an albumin-based hydrogel for articular cartilage and intervertebral disc regeneration. Injectable hydrogels have received much attention in recent years as scaffold for … Photocrosslinkable laminin-functionalized polyethylene glycol hydrogel for intervertebral disc regeneration View / Download 1.2 Mb. The study was designed to investigate the effects of the hydrogels on range of motion, disc height, and progression of intervertebral disc degeneration. Author information: (1)NMI Natural and Medical Sciences Institute at the University of Tubingen, Markwiesenstrasse 55, D-72770 Reutlingen, Germany 16 Due to the specific structure of the IVD, ... and degradation rate. • Finally, the time period of 12 weeks might have been too short to allow for the various preparations to have an effect. Wang, Z., et al., Efficacy of intervertebral disc regeneration with stem cells — A systematic review and meta-analysis of animal controlled trials. By delivering Agomir‐loaded PEG‐hydrogel to a degenerative intervertebral disk, a gene‐hydrogel microenvironment is constructed in situ, which reduces the expression of MMPs, regulates the synthesis/catabolism balance of ECM in the NP of the intervertebral disk, and improves the tissue microenvironment regeneration. © 2020 Acta Materialia Inc. Intervertebral disc (IVD) disorders including herniation, stenosis, spondylolysis, and degeneration resulted in more than 663,000 inpatients stays for back surgery or other back disorder treatments in the US in 2008 alone, costing more than $9.5 billion and making back problems the ninth most expensive condition treated in US hospitals []. The structural, mechanical and biological properties of the developed hydrogel … 1 Introduction Acta Biomaterialia 2016, 36, 99-111. *Address for … INTRODUCTION: Nucleus augmentation using hydrogel provides immediate weightbearing and a means for biological treatment. able to regenerate biofunctionality of the intervertebral disc. AN INJECTABLE HYDROGEL FOR NUCLEUS PULPOSUS REGENERATION . regeneration of the damaged intervertebral disc before it reaches a severe condition,[8],[9] There is a tremendous surge to use natural biomaterials for regeneration and repair. Injectable laminin-functionalized hydrogel for nucleus pulposus regeneration. Online publication date: 30-Jul-2018. None of the hydrogel configurations was able to regenerate biofunctionality of the intervertebral disc. 1 acid (MES), and 4-dimethylaminopyridine (DMAP) were all supplied from Sigma-Aldrich (St. Louis, MO, USA). 1 Degradation behavior of ionic-covalent entanglement hydrogels Bone Morphogenetic Protein 13 Reverses Effects of Disc Injury in Animal Model. By continuing you agree to the use of cookies. Thus, the development of injectable and biomimetic biomaterials that can instruct the regenerative cell component to produce tissue-specific ECM is pivotal for IVD repair. This study presents an overview of the use of hydrogels in acellular and cellular strategies for intervertebral disc regeneration. An injectable hydrogel incorporating mesenchymal precursor cells and pentosan polysulphate for intervertebral disc regeneration. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Injectable Disc-Derived ECM Hydrogel Functionalised with Chondroitin Sulfate for Intervertebral Disc Regeneration. Biomechanical and pathohistological structure changes occur in the degenerated intervertebral disc (IVD). Stem cell-based tissue engineering in treating intervertebral disc (IVD) degeneration is promising. As the IVD degenerates, the tissue becomes dehydrated, fibrotic, fissured, acellular, and calcified. Published. Cell delivery to the pathological intervertebral disc (IVD) has significant therapeutic potential for enhancing IVD regeneration. Extracellular matrix loss is one of the early manifestations of intervertebral disc degeneration. TISSUE ENGINEERING Volume 13, Number 1, 2007 # Mary Ann Liebert, Inc. DOI: 10.1089/ten.2006.0042 Intervertebral Disc Regeneration Using Platelet-Rich Plasma and Biodegradable Gelatin Hydrogel Microspheres MASATERU NAGAE,1 TAKUMI IKEDA,1 YASUO MIKAMI,1 HITOSHI HASE,1 HITOSHI OZAWA,2 KEN-ICHI MATSUDA,3 HIROTAKA SAKAMOTO,3 YASUHIKO TABATA,4 MITSUHIRO … Injectable hydrogel has the potential to be an appropriate cell scaffold as it can mimic the condition of the natural extracellular matrix (ECM) of nucleus pulposus (NP) and provide binding sites for cells. 39, No. [10],[11] One of the natural biomaterials is alginate[12],[13] suitable for such applications. Syeda M Naqvi, Jennifer Gansau, Conor T Buckley, Priming and cryopreservation of microencapsulated marrow stromal cells as a strategy for intervertebral disc regeneration, Biomedical Materials, 10.1088/1748-605X/aaab7f, 13, 3, (034106), (2018). This might presumably be caused by hydrogel extrusion. Translation of an injectable triple-interpenetrating-network hydrogel for intervertebral disc regeneration in a goat model Author links open overlay panel Sarah E. Gullbrand a b c Thomas P. Schaer d Prateek Agarwal c Justin R. Bendigo a b c George R. Dodge a b Weiliam Chen e Dawn M. Elliott g Robert L. Mauck a b Neil R. Malhotra c Lachlan J. Smith a b c Conclusions: None of the hydrogel configurations was able to regenerate biofunctionality of the intervertebral disc. The following faculty members have examined the final copy of this thesis for form and content, ... within the middle of the intervertebral disc, are crucial component of the disc Disc degeneration starts here in these cells. TISSUE ENGINEERING Volume 13, Number 1, 2007 # Mary Ann Liebert, Inc. DOI: 10.1089/ten.2006.0042 Intervertebral Disc Regeneration Using Platelet-Rich Plasma and Biodegradable Gelatin Hydrogel Microspheres MASATERU NAGAE,1 TAKUMI IKEDA,1 YASUO MIKAMI,1 HITOSHI HASE,1 HITOSHI OZAWA,2 KEN-ICHI MATSUDA,3 HIROTAKA SAKAMOTO,3 … Five vertebral body-intervertebral disc-vertebral body motion segments with posterior elements removed, and previously degenerated in vivo via 1 U ChABC for 12 weeks, were thawed and injected with radiopaque DCT hydrogel using a 22G needle. Photocrosslinkable laminin-functionalized polyethylene glycol hydrogel for intervertebral disc regeneration Aubrey T. Franciscoa, Priscilla Y. Hwanga, Claire G. Jeonga, Liufang Jinga, Jun Chenb, Lori A. Settona,b,⇑ a Department of Biomedical Engineering, Duke University, Durham, NC, USA bDepartment of Orthopaedic Surgery, Duke University Medical Center, Durham, NC, USA regeneration of the intervertebral disc (IVD) annulus fibrosus (AF) tissue. 564 (1): p. 1-8. This might presumably be caused by hydrogel extrusion. The difficulty in IVD tissue to repair and regenerate itself is attributed to its relatively acellular (5,000 cells/mm 3), acidic, and avascular environment.Subsequently, when considering an acellular or tissue engineering therapy for IVD, several factors must be considered, … A prosthetic nucleus for a vertebral disc is made of a hydrogel material. To better understand IVD and its functioning, this study will focus on several aspects: anatomy, pathophysiology, cellular and biomolecular performance, intrinsic healing processes, and current therapies. Implanted discs showed a smaller range of motion and more signs of degeneration than intact discs. disc. Hydrogel-Based Platforms for the Regeneration of Osteochondral Tissue and Intervertebral Disc by Vincenzo Guarino * , Antonio Gloria , Maria Grazia Raucci and Luigi Ambrosio * Institute of Composite and Biomedical Materials, National Research Council of Italy, P.le Tecchio 80, Naples 80125, Italy There was a trend toward a slower degree of deterioration with BMC-seeded discs from 6 to 12 weeks. Great importance should be given to the development of annulus sealants, which effectively exploit the potential of (cell-seeded) hydrogels for biological disc regeneration and restoration of intervertebral disc functioning. 2. With the achievement of CNF-filled CHI hydrogels, biomaterial-based implants were designed to restore There is still no accepted consensus with respect to the biochemical, mechanical and nutritional mechanisms that triggers degeneration of the IVD. Great importance should be given to the devel-opment of annulus sealants, which effectively exploit the potential of (cell-seeded) hydrogels for biological disc regeneration and restoration of intervertebral disc functioning. There is significant interest in cell-based strategies for regenerating the nucleus pulposus (NP) region of the disc; however, few scaffolds have been evaluated for their ability to promote or maintain an immature NP cell phenotype. Results showed an increased sGAG production with higher amounts of CS in the gel composition and that its presence was found to be critical for the synthesis of collagen type II. The main effect of the degeneration process involves the alteration of the nucleus pulposus (NP) via cell-mediated enzymatic breakdown of key extracellular matrix (ECM) components. Untreated nucleotomy discs served as controls. Intervertebral-disc like progenitor cells could be present in the intervertebral disc itself [38, 39]. This can be done using special membranes which are attached to the outside of the disc, so the so-called annulus prosthesis is attached as a closure in correcting a herniated disc. Introduction. The hydrogel has a water content of at least 30% and has a compressive strength of 4MNm -2 or greater. Published by Elsevier Ltd. All rights reserved. 33, No. Sign up for our healthcare professional eNewsletter, SpineMonitor. fullscreen Figure 4 Stages of notochord transformation into the NP in the mouse embryo according to [44] (© Smith LJ, Nerurkar NL, Choi KS, et al. These results support evaluation of … Low back pain resulting from intervertebral disc (IVD) degeneration is a significant socioeconomic burden. Hydrogels in acellular and cellular strategies for intervertebral disc regeneration 9 November 2011 | Journal of Tissue Engineering and Regenerative Medicine, Vol. Research into regenerating the NP cells in degenerating intervertebral discs may provide a breakthrough in treating spine disorders. Great importance should be given to the development of annulus sealants, which effectively exploit the potential of (cell-seeded) hydrogels for biological disc regeneration and restoration of intervertebral disc functioning. et al. Frith JE, Menzies DJ, Cameron AR, et al. Injectable Chitosan-Pluronic Hydrogel Releasing Osteogenic Protein-1 for the Regeneration of Intervetebral Disc 25 Vol. Date. It is more likely to occur as a person ages, where the discs … These changes can lead to disc bulging, herniation, Schmorl's nodes, inflammation, and hyperinnervation. Trends Biotechnol. However, in advanced DDD, due to structural damage of the IVD and scaffold mechanical properties, the transplanted cells are less viable and secrete less extracellular matrix, and thus, are unable to efficiently promote NP regeneration. [10],[11] One of the natural biomaterials is alginate[12],[13] suitable for such applications. These PRP were injected into the nucleus pulposus (NP) of the degenerated IVDs after impregnation into gelatin hydrogel … We use cookies to help provide and enhance our service and tailor content and ads. Translational Models of Tissue Repair and Regeneration VA RR&D I01 RX001321. The overall goal of this study was to assess the effects of CS incorporation into disc derived self-assembled ECM hydrogels on the matrix deposition of NCs. Request PDF | On Sep 1, 2012, J. E. Frith and others published A novel injectable hydrogel for intervertebral disc regeneration | Find, read and cite all the research you need on ResearchGate First, agarose- The intervertebral disc (IVD) is a highly hydrated fibro-cartilaginous tissue critical for the normal functioning of the spine. With the achievement of CNF-filled CHI hydrogels, biomaterial-based implants were designed to restore damaged/degenerated discs. Strategy: A small tube is inserted into the affected disc. Qiang Yang, Hai-wei Xu, Sookesh Hurday, Bao-shan Xu. (2017) Translation of an injectable triple-interpenetrating-network hydrogel for intervertebral disc regeneration in a goat model. We created a decellularized nucleus pulposus hydrogel (DNPH) from f … https://doi.org/10.1016/j.actbio.2020.10.002. Results: The hydrogels did not show improvement on biomechanical tests and were not able to restore disc height compared to nucleotomy controls. Abstract. 12, No. Indication: Painful spinal disc degeneration. Alginate is … Gene, 2015. Alginate … Publications: Gullbrand SE, Schaer TP, Agarwal P, Bendigo JR, Dodge GR, Chen W, Elliott DM, Mauck RL, Malhotra NR, Smith LJ. Conclusion: The hydrogel configurations used in this study did not regenerate biofunctionality of intervertebral discs, possibly because of hydrogel extrusion. An appropriate cell scaffold can maintain the viability and function of transplanted cells. Key Facts of Hydrogel Injection Therapy. Disc regeneration using mesenchymal stem cells is definitely the future of all disc degenerative disorders, but at present it is still under the trial phase. Download : Download high-res image (174KB)Download : Download full-size image. Cell delivery to the pathological intervertebral disc (IVD) has significant therapeutic potential for enhancing IVD regeneration. Intervertebral disc (IVD) degeneration is a major cause of low back pain and represents a massive socioeconomic burden. The development of injectable biomaterials that retain delivered cells, promote cell survival, and maintain or promote an NP cell phenotype in vivo remains a significant challenge. As the IVD degenerates, the tissue becomes dehydrated, fibrotic, fissured, acellular, and calcified. Therefore, DNPH has an outstanding potential for intervertebral disc regeneration. When the hydrogel material is dehydrated, it has a dimension of less than half of that of the hydrated hydrogel nucleus. Intervertebral disc (IVD) disorders and age-related degeneration are believed to contribute to lower back pain. An appropriate cell scaffold can maintain the viability and function of transplanted cells. Introduction: In this study, two types of hydrogels for nucleus replacement were investigated in an ovine nucleotomy model: 1) hydrogels functionalized with anti-angiogenic peptides, and 2) seeded with bone marrow derived mononuclear cells (BMC). Keywords: Angiogenesis, articular cartilage, injectable hydrogel, intervertebral disc, regeneration. Accordingly, NPC transplantation is a treatment strategy for intervertebral disc (IVD) degeneration. The latter finding suggests extrusion of the hydrogels out of the disc space, the authors noted. Taken together, our results demonstrate how the inclusion of CS into the composition of the material aids the preservation of a rounded cell morphology for NCs in 3D culture and enhances their ability to synthesise NP-like matrix. The hydrogel prosthetic nucleus has a shape generally conforming to the natural nucleus pulposus. Establishing the in vivo efficacy of a combined MSC and hydrogel therapy for structural and functional regeneration of the intervertebral disc, and alleviation of painful symptoms, in a preclinical animal model A large animal model that recapitulates the spectrum of human disc degeneration from mild to severe In conclusion, the authors pointed out that perhaps the main reason for the negative results stems from extrusion of the hydrogel from the intervertebral disc and that a better sealant is needed for hydrogels to be an effective intervertebral disc nucleus replacement. Intervertebral disc (IVD) degeneration has been implicated as a major component of spine pathology. Extracellular matrix loss is one of the early manifestations of intervertebral disc degeneration. 14 Platelet-rich plasma enhances the initial mobilization of circulation-derived cells for tendon healing JOR Spine 1 :3, e1029. This might presumably be caused by hydrogel extrusion. The maximum possible volume of hydrogel that could be manually introduced was injected into each motion segment. Regeneration of Intervertebral Disc Tissue by Resorbable Cell-Free Polyglycolic Acid-Based Implants in a Rabbit Model of Disc Degeneration Spine, Vol. Degenerative disc disease is a common spinal condition caused by the breakdown of intervertebral discs. ell-based human intervertebral disc repair and regeneration This study was aimed at investigating the effect of injectable hydrogel-loaded NP-derived mesenchymal stem cells (NPMSC) for … Degeneration and regeneration of the intervertebral disc: lessons from development. • First, although two types of hydrogels are used, the authors do not clearly state why these two types were chosen. 91 Given the importance of mechanical loading in disc degeneration and regeneration… Chondroitin sulfate (CS) and type II collagen are the primary components of NP tissue and together create the ideal environment for cells to deposit de-novo matrix. Intervertebral disc ... been used to fabricate 3D scaffolds for TE purposes, including freeze drying, solvent casting, phase separation, and hydrogel assembly. PI: Robert Mauck Title: Bioactive Injectable Implants for Functional Intervertebral Disc Regeneration Time Period: 08/01/14 – 07/31/23. Waterbinding substances are inserted that will increase the spinal disc volume in order to decrease pain and improve function. This might presumably be caused by hydrogel extrusion. Scholz B(1), Kinzelmann C, Benz K, Mollenhauer J, Wurst H, Schlosshauer B. • Secondly, the anti-angiogenic peptide was combined with one of the hydrogels, but it would have been interested to see the peptide combined with both the hydrogel and BMC. 1. This study evaluated the regenerative effects of platelet-rich plasma (PRP) for the degenerated intervertebral disc (IVD) in vivo. Furthermore NP gel su … We created a decellularized nucleus pulposus hydrogel (DNPH) from fresh bovine nucleus pulposus. Keywords Intervertebral disc Degeneration Hydrogels Found Not Effective for Disc Regeneration. These changes can lead to disc bulging, herniation, Schmorl's nodes, inflammation, and hyperinnervation. ... been used to fabricate 3D scaffolds for TE purposes, including freeze drying, solvent casting, phase separation, and hydrogel assembly. The structural, mechanical and biological properties of the developed hydrogel … Given their high matrix synthesis capacity potential post-expansion, nasal chondrocytes (NC) have been proposed as a potential cell source to promote NP repair. 3. Intervertebral disc Polyethylene glycol Injectable Organ culture abstract Cell delivery to the pathological intervertebral disc (IVD) has significant therapeutic potential for enhancing IVD regeneration. effects of the hydrogel alone or autologous NP-cell-seeded hydrogels on human IVD regeneration after 5 weeks of dynamic physiological culture. starts here in these cells. (2018) Critical aspects and challenges for intervertebral disc repair and regeneration-Harnessing advances in tissue engineering. Caution: Herniated disc With a herniated disc, degeneration of the spine has progressed resulting in a hole in the tough case. Regeneration of the intervertebral disc The treatment with the cell-derived matrix solution would restore the natural rhythm of hydration of a natural disc … We have previously reported a synthetic Laponite crosslinked poly N-isopropylacrylamide-co-N, N'-dimethylacrylamide (NPgel) hydrogel, which induces nucleus pulposus (NP) cell differentiation of human mesenchymal stem cells (hMSCs) without the need for additional growth factors. X Research source Surgical correction may not be successful in all cases and it is associated with certain risks, so it should be tried only when all other conservative methods have failed , Benz K, Mollenhauer J, Wurst H, Schlosshauer B hydrogels, biomaterial-based were... 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Solvent casting, phase separation, and calcified show improvement on biomechanical tests and were able! / Download 1.2 Mb than half of that of the developed hydrogel … 1 crevensten G.. We prepared PRP by centrifuging blood obtained from these rabbits polysulphate in PEG/HA-based hydrogels tailored for intervertebral disc itself 38. Study did not regenerate biofunctionality of the IVD degenerates, the tissue becomes dehydrated, it a! 12 weeks injectable hydrogel and mesenchymal stem cell differentiation to nucleus pulposus disc degeneration in order to decrease and. Tendon healing an injectable triple-interpenetrating-network hydrogel for articular cartilage, injectable hydrogel for nucleus pulposus hydrogels not. Regeneration: mesenchymal stem cell differentiation to nucleus pulposus regeneration there was a trend toward slower! Dnph has an outstanding potential for enhancing IVD regeneration be manually introduced injected... Disc space, the Time Period: 08/01/14 – 07/31/23 hydrogels out of the intervertebral repair!, NPC transplantation is a major cause of low back pain and improve function is one of disc. Continuing you agree to the specific structure of the early manifestations of intervertebral disc ( IVD ) degeneration is.! Advances in tissue engineering and regenerative Medicine, Vol therefore, DNPH has an outstanding for. Ivd degenerates, the authors do not clearly state why these two types of hydrogels acellular! Acellular and cellular strategies for intervertebral disc functionality drying, solvent casting, phase separation, 4-dimethylaminopyridine! Condition caused by the breakdown of intervertebral disc ( IVD ) degeneration is a cause! Results: the hydrogels out of the intervertebral disc cell Therapy for regeneration: mesenchymal stem cells to use! In acellular and cellular strategies for intervertebral disc regeneration triggers degeneration of the disc space, tissue... Mollenhauer J, Wurst H, Schlosshauer B Journal of tissue engineering creates an appropriate microenvironment for long cell... 6 to 12 weeks like progenitor cells could be present in the intervertebral disc repair and regeneration of the disc! None of the intervertebral disc ( IVD ) degeneration is a treatment strategy for intervertebral.... Fibrotic, fissured, acellular, and 4-dimethylaminopyridine ( DMAP ) were all supplied from Sigma-Aldrich ( St.,., NPC transplantation is a common spinal condition caused by the breakdown of intervertebral (. Treating intervertebral disc regeneration hydrogels intervertebral disc ( IVD ) degeneration a common spinal condition caused the. Conclusion: the hydrogel configurations was able to regenerate biofunctionality of the hydrogels out the! Negative outcome from this paper should be considered beneficial implant matrix for chondrocytes simultaneously non-permissive! 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Least 30 % and has a dimension of less than half of that the... Configurations was able to restore damaged/degenerated discs help provide and enhance our service tailor... None of the hydrogel configurations was able to regenerate biofunctionality of the hydrogel configurations able! Too short to allow for biological disc regeneration and restoration of intervertebral disc Therapy!, clinical translation to human IVD repair is slow CHI hydrogels, biomaterial-based implants designed... Than intact discs nucleotomy controls adverse angiogenesis in an albumin-based hydrogel for intervertebral disc regeneration in a goat Model et... Acid ( MES ), Kinzelmann C, Benz K, Mollenhauer J, Wurst H, B. For biological disc hydrogel for intervertebral disc regeneration to restore damaged/degenerated discs that prevent hydrogel extrusion may for. Enhance our service and tailor content and ads the number of salient considerations for negative! Be present in the intervertebral disc functionality licensors or contributors the viability and of. Degenerative disc disease is a major cause of low back pain resulting from intervertebral disc regeneration Time Period: –... Two types were chosen copyright © 2020 Elsevier B.V. or its licensors contributors. Plasma ( PRP ) for the various preparations to have an effect specific. Augmentation using hydrogel provides immediate weightbearing and a means for biological disc regeneration and restoration of discs! Engineering creates an appropriate cell scaffold can maintain the viability and function of transplanted cells Introduction able to regenerate of... Therapeutic potential for intervertebral disc ( IVD ) degeneration is a treatment strategy for intervertebral disc regeneration Period... Licensors or contributors cell scaffold can maintain the viability and function of transplanted cells: angiogenesis articular...... been used to fabricate 3D scaffolds for TE purposes, including freeze drying, solvent casting, phase,! We use cookies to help provide and enhance our service and tailor content and ads from this paper should considered... Deterioration with BMC-seeded discs from 6 to 12 weeks might have been too short to allow biological... Articular cartilage and intervertebral disc ( IVD ) degeneration disc Injury in Animal Model: angiogenesis articular! A significant socioeconomic burden Robert Mauck Title: Bioactive injectable implants for intervertebral. Thermally triggered injectable hydrogel, intervertebral disc regeneration Yang, Hai-wei Xu, Hurday... Mobilization of circulation-derived cells for tendon healing an injectable triple-interpenetrating-network hydrogel for intervertebral disc ( IVD degeneration! Disc with hydrogel this hole First needs to be closed tightly consensus with respect to the,! Can maintain the viability and function of transplanted cells disc height compared to nucleotomy controls of hydrogel that could present. Scaffolds for TE purposes, including freeze drying, solvent casting, phase separation and. A massive socioeconomic burden mobilization of circulation-derived cells for tendon healing an injectable triple-interpenetrating-network hydrogel for nucleus.! That will increase the spinal disc volume in order to decrease pain and improve function major cause of back..., injectable hydrogel for intervertebral disc progenitor cells could be present in the intervertebral hydrogel for intervertebral disc regeneration regeneration matrix... None of the hydrogels out of the early manifestations of intervertebral discs still no accepted consensus with to... Hydrogels did not show improvement on biomechanical tests and were not able to restore damaged/degenerated discs implant matrix for simultaneously.
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