Avoid use in children. A. Wintergreen oil is POSSIBLY UNSAFE to take by mouth. Author information: (1)a Utah Poison Control Center, College of Pharmacy , University of Utah , Salt Lake City , Utah , USA. Topical - Oil of Wintergreen (1 tsp 98% salicylate = 7000mg), Dencorub, some teething gels; Alternative medicine - Willow bark; Assessment Features on history. Serious toxicity can result from exposure to small amounts of methyl salicylate. Oil of wintergreen: extremely high level of methyl salicylate (1.4g/mL). Uncouples oxidative phosphorylation → increased metabolic rate and hyperthermia. a. This conversion illustrates the potency and potential toxicity of oil of wintergreen even in small quantities. Wintergreen (Gaultheria procumbens) is a perennial, aromatic herb native to the Eastern areas of North America.Commonly found in mountainous terrain, the shrubby plant blooms with white flowers and bright, red berries. Oil of wintergreen contains 98 percent methyl salicylate, so it’s highly toxic in its pure form. Pepto-Bismol; Wart removers; Maalox; Alka-Seltzer; Pathophysiology . Tea tree oil–In high concentrations tea tree essential oil (aka melaleuca) can cause adverse effects; however, shampoos containing low concentrations are okay. Further information: Methyl salicylate § Safety and toxicity. Pathophysiology. Toxicity of wintergreen oil. This conversion illustrates the potency and potential toxicity of oil of wintergreen even in small quantities. Methyl salicylate is an important potential source of salicylate toxicity in the pediatric population. Salicylate poisoning is the result of ingestion of, or (rarely) topical exposure to, chemicals metabolized to salicylate. Wintergreen is used in some over-the-counter skin preparations to relieve pain. Dosage formulation must be considered when predicting toxicity. Wintergreen essential oil (and birch due to similarity in chemistry) is a powerful essential oil. Methyl salicylate is widely available as a component in many over-the-counter brands of creams, ointments, lotions, liniments and medicated oils intended for topical application to relieve musculoskeletal aches and pains. Pennyroyal (aka squawmint)–This oil is sometimes used in products to treat fleas. If you’ve ever taken an aspirin, then you’ve used wintergreen! One teaspoon (5 mL) of Oil of Wintergreen contains approximately 7 g of Salicylate which is equivalent to 21.7 adult aspirin tablets; Bismuth Salicylate (active ingredient in Pepto-Bismol) contains 8.7 mg of salicylic acid per mL. Ingestion of < 5 mL of oil of wintergreen can kill a young child. Salicylate toxicity can be life-threatening. PMID: 31267790 Wintergreen oil has been shown to be beneficial in the restoration of the flexibility to hardened rubber components. Avoid use in patients with known allergy to any parts of wintergreen oil and in patients with known allergy to pain relievers like aspirin, or with GI problems. Toxicity of Wintergreen oil. 30 mL (about 1 fl oz) of oil of wintergreen is equivalent to 55.7 g of aspirin, or about 171 adult aspirin tablets (US). can Wintergreen Oil cause Toxicity? However, bulk sizes larger than 2 oz do not. Wintergreen. In a massage oil blend methyl salicylate is found in the blood 20 to 30 minutes after application. WIntergreen Oil–This oil contains methyl salicylates, also commonly known as aspirin. Oil of wintergreen is another name for methyl salicylate, a relative of aspirin (acetylsalicylic acid). Salicylate toxicity from ingestion of an oil of wintergreen containing insecticide Clin Toxicol (Phila). The flowers of the wintergreen plant are bell-shaped and white. Delayed absorption with ... Salicylate (Aspirin (ASA), Methyl salicylate/Oil of wintergreen) Version 1: Published 7/2017. Toxicity to pets. Wintergreen Oil is mentioned in 42 posts about Toxicity. These ointments and oil have a pleasant smell, leading to accidental ingestions in toddlers which may be fatal [1,2]. Acute Toxicity Wintergreen oil Oral LD50 (Rat) 887 mg/kg (Methyl salicylate CAS 119-36-8) Dermal LD50 (Rabbit) >5000mg/kg (Methyl salicylate CAS 119-36-8) Specific Target Organ Toxicity (STOT) – single exposure No relevant studies identified. A massage oil blend should not contain more than 1-2% Wintergreen. CONCLUSION: Plasma salicylate concentrations from methyl salicylate cream are not equal to those achieved after ingestion of oil of wintergreen. NSAID, acetylsalicylic acid, ASA, salicylic acid, BenGay, salicylates, HEET, Icy Hot, Pepto-Bismol, oil of wintergreen. Toxicity of oil. (2)b Division of Emergency Medicine , University of Utah , Salt Lake City , Utah , USA. Wintergreen Essential Oil. One teaspoon (5 mL) of wintergreen oil is equivalent to approximately aspirin 7 g or 21.5 (325 mg) adult aspirin tablets. Treatment is identical to the other salicylates. Continuous use seems the most worrying for toxicity. In dogs, the most common essential oil toxicities that we see are to Melaleuca or Tea Tree Oil, Pennyroyal, Oil of Wintergreen, and Pine Oils. Is Wintergreen Oil helpful for Toxicity? Which finding suggests a complication of the toxic ingestion of oil of wintergreen? Poisoning may occur due to acute or chronic salicylate exposure and is characterized by acid-base disturbances, electrolyte abnormalities, and central nervous system effects. Research indicates it can take as little as 15 minutes following ingestion to identify traceable amounts in the blood, with a peak around 2 hours following ingestion. BUT – a big but – oil of wintergreen is very dangerous if more than a tiny amount is swallowed. Epub 2019 Jul 3. Topical Use of Wintergreen Essential Oil The topical use of Wintergreen is less toxic but still of concern. A. Bradycardia B. Diaphoresis C. Hypothermia D. Lethargy. Small amounts of oil of wintergreen, like small amounts of aspirin, can poison children. Salicylate toxicity from ingestion of an oil of wintergreen containing insecticide. It has an almost straight stem accompanied by shiny and glossy leaves. Salicylate ingestion causes decreased platelet function that can lead to petechiae. [5] Illiteracy may be a common factor in accidental overdoses and ingestions in adults [citation needed]. Contraindications. Which finding is a sign of serotonin syndrome? Per the Safety Considerations below, this product MUST be kept out of reach of children due to potential toxicity. Toxicity / Risk Assessment Management Toxicity is dose-dependent. As level rises, switches from hepatic to renal clearance (slower) Nausea/vomiting. Health hazards Acute toxicity, oral Category 4 Skin corrosion/irritation Category 2 Serious eye damage/eye irritation Category 2A Hazardous to the aquatic environment, Category 3 long-term hazard Environmental hazards Label elements. PLEASE NOTE: Retail sizes (15 ml and 30 ml) of this product come with a child-proof cap and orifice reducer. Producers of wintergreen oil extract the wintergreen oil from the Gaultheria procumbens plant. We have certainly seen an increase in essential oil toxicity in recent years due to the increase in pet owner’s desire to treat more holistically or with natural remedies. A. Petechiae B. Metabolic alkalosis C. Jaundice D. Bradycardia. Oil of wintergreen (methyl salicylate) is a highly toxic, liquid form of salicylate used in products such as BENGAY. Ingestion of topical products containing salicylates (eg, Ben-Gay, salicylic acid [keratolytic], oil of wintergreen or methyl salicylate), can cause severe salicylate toxicity. Aspirin (also known as acetylsalicylic acid or ASA) is a common over-the-counter (OTC) non-steroidal anti-inflammatory (NSAID) used in both human and veterinary medicine. - Page 2 Relative bioavailability for the low-dose treatment was 0.5 compared to oil of wintergreen. Organic Wintergreen Essential Oil. Salicylates disrupt aerobic metabolism by uncoupling oxidative phosphorylation, leading to lactate and ketone accumulation. Early diagnosis and treatment are critical. Taking wintergreen oil can cause ringing in the ears, nausea, vomiting, diarrhea, headache, stomach pain, and confusion. Signs of Reproductive toxicity - Wintergreen Oil including medical signs and symptoms of Reproductive toxicity - Wintergreen Oil, symptoms, misdiagnosis, tests, common medical issues, duration, and the correct diagnosis for Reproductive toxicity - Wintergreen Oil signs or Reproductive toxicity - Wintergreen Oil … PMID: 12870876 [Indexed for MEDLINE] It creates a feeling of warmth because it causes blood vessels to enlarge. Salicylate toxicity from ingestion of an oil of wintergreen containing insecticide. Thirty ml (about 1 fl oz) of oil of wintergreen is equivalent to 55.7 g of aspirin, or about 171 adult aspirin tablets (US). Even small doses of oral wintergreen oil may cause toxicity. In herbal medicine, we would call this something akin to a low dose botanical. (Keep in mind, however, that one would have to eat spoonfuls of ointment to ingest a teaspoon’s worth of the oil.) 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