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Although these may still be high quality, the active compounds are more likely to vary. Chemistry. In another study, 61 children with ADHD were given one mg per kg/day of Pycnogenol or placebo over four weeks. The staff there can often answer any questions you have and give you more information about specific brands. Two doses of 100 mg of Pycnogenol were taken two to three hours before flights and two additional capsules taken six hours later then one capsule the next day. Helps Increase Athletic Performance. DOI: Marini A, et al. WebMD does not provide medical advice, diagnosis or treatment. A Pycnogenol combination product (with l-arginine, alpha lipoic acid, B vitamins, and vitamin K2) may help protect the blood vessels and reduce high homocysteine levels, according to a trial of 25 people [39]. , Allergy: "Leukotriene E4 plasma levels in adult asthmatic patients with variable disease severity. Pycnogenol has been well-tolerated in most studies performed thus far. In one study, 200 mg a day of Pycnogenol taken three hours prior to the first cigarette for the day for two months significantly reduced cigarette-induced platelet aggregation. whole-body health. In a study of 20 postmenopausal women, 12 weeks of pycnogenol supplementation improved hydration and elasticity of the skin. nausea. This study adds to a body of research showing the benefits of Pycnogenol . After stopping Pycnogenol for one month, symptoms The flesh of the grape contains approximately 1/20th-1/100th of the total antioxidant capacity of the seed or the skin. Researchers suggest this benefit may be due to an increase in glutathione and SOD, two antioxidants that may reduce inflammation and oxidative stress in Crohns [76]. Pycnogenol is a standardized supplement formula guaranteed to contain at least 65-75% proanthocyanidins, the active . It can also be found as creams, lotions or ointments, typically containing 0.5 percent to 2 percent pine bark extract. Some people who have asthma have higher levels of leukotrienes in their blood. Symptoms of menopausal syndrome, also known as climacteric syndrome, include: hot flashes; chills; headache; and depression. A 2021 review in the Arab Journal of Urology listed it first among "promising herbal remedies" for ED. Ac., CYT, 12 Benefits of Ginkgo Biloba (Plus Side Effects & Dosage), Tongkat Ali (Eurycoma longifolia): Everything You Need to Know, reduce blood sugar levels in people with diabetes, are within two weeks of a scheduled surgery, medications, herbs, and supplements that affect the blood or clotting. In a third study, 19 men with fertility problems were given 200 mg Pycnogenol daily for 90 days. Pycnogenol (150 mg/day) reduced pain in a study of 100 people with osteoarthritis after 3 months. All Pycnogenol-treated patients responded favorably in contrast to placebo treatment. . 2005 - 2023 WebMD LLC. In another good study, 48 patients with diabetes and high blood pressure on ACE inhibitors were randomized to receive either Pycnogenol 125 mg daily or placebo for 12 weeks. Vinpocetine is used to increase brain circulation, alertness, cognitive function, concentration, and memory, as well as to lower inflammation and oxidative stress.This article will explore vinpocetine's history, how it works, its potential benefits, and any possible safety issues . Consequently, blood pressure is lowered. Set Ascending Direction. 11 Skin elasticity increased, and skin fatigue decreased significantly in this study as well, further lowering the wrinkling risk. Pycnogenol was featured on The Dr. Oz Show in January 2013, . Pycnogenol accelerates wound healing and reduces scar formation [Abstract]. Due to its anti-inflammatory properties, luteolin is being researched as a potential complementary treatment for multiple . Researchers from the study suggest that low Pycnogenol dosage and short study duration may explain the lack of benefits [44]. Pycnogenol (100 mg/day) may reduce leg swelling, spider veins, and cramps according to a study of 133 women with varicose veins who recently gave birth. The goal of one study was to evaluate whether or not Pycnogenol could prevent edema (fluid build-up) during long-haul flights in healthy people. In a study of 76 people with allergic asthma, Pycnogenol (100 mg/day) added to conventional corticosteroid inhalers for 6 months helped 55% of them reduce inhaler use frequency and dosage. A randomized clinical trial of 30 people found that Pycnogenol (150 mg/day) may help heal vein ulcers from surgery and reduce swelling after 3 months of treatment [25]. Pycnogenol acts as a sustained-release formulation. returned. 2. Studies were conducted in Turkey on subjects who underwent abdominal surgery to determine if the pine bark extract could help reduce the inflammation. Next, the doctors discuss the link between salt and hypertension, and Dr. Steve gives his insight on drinking red wine for a healthy heart. In another study, Pycnogenol increased glutathione levels and total antioxidants after a month in children with ADHD [42, 43]. In addition to OPC, grape seed extract contains linoleic acid, flavonoids and phenolic procyanidins that help protect and strengthen capillaries, blood vessels, veins and arteries, which can then improve blood circulation. Pycnogenol French maritime pine bark extract's 4 basic properties. A trial of 84 people found that both Pycnogenol oral supplements and creams (0.5%) may prevent hemorrhoids from bleeding during acute attacks after 7 days. One way to add some extra flavor and nutrients to your day is by adding prune juice to your diet. Prunes and prune juice have many health benefits. Also, be sure to talk with your doctor first if you have an underlying medical condition or take other medications. However, these studies appear to be methodologically sound and reliable, with no blatant errors in the study design and data collection. For poor circulation: 45360 milligrams daily or 50100 milligrams three times daily. Also, its important to note that some of these studies were funded by Horphag Research, the original developers and exclusive marketers of Pycnogenol. According to the lab results of 10 volunteers, a higher Pycnogenol dose (300 mg) may impact these enzymes after just 30 minutes [52]. You may want to start slow, taking smaller amounts, to ensure that your body works well with the OPCs found in pine bark extract. Pycnogenol seems well-tolerated for use in adults for up to 6 months. In a study of 77 people with symptoms of Irritable Bowel Syndrome (IBS), Pycnogenol (150 mg/day) improved symptoms and reduced the frequency of attacks [77]. Blood clots form as a result of platelet aggregation, which is the platelets in the blood clumping together. However, it can also be used topically. Pycnogenol is the US trademarked name for an antioxidant made from Mediterranean tree bark. In oneparticular study published in Research in Pharmaceutical Sciences, researchers investigated the antibacterial activity of pine bark extract essential oil on staph infections, E. coli and pseudomonas infections. During week, five without, treatment, reduction of cramps was maintained in all three groups. With time, the participants were able to handle more UV radiation without experiencing skin damage [63]. However, it is also important to see beyond the pyncogenol marketing campaign and understand the possible dangers associated with this natural supplement. Almost 400 years later, Dr. Jacques Masquelier from France came across Cartiers account and started to look for the active ingredients from the bark of the tree. It also appeared to improve their attention span, visual motor skills, and concentration. Regardless, a natural option is available and far worth the wait. In one trial of 77 people with type 2 diabetes, pycnogenol (100 mg/day) for 12 weeks lowered both blood sugar levels and HbA1c, a marker of long-term blood glucose levels [31]. However, some of these other pine bark extracts can have different active compounds, which may affect their biological activity. Let us discuss them in detail below. New research has shown promising results for those dealing with erectile dysfunction (ED) and diabetes. Plus, it reduced total and LDL (bad) cholesterol. Studies on human subjects have reported few side effects - even . Studies have also safely used Pycnogenol in children and during pregnancy. In one human study, some of the reported side effects of chanca piedra supplementation included: abdominal pain. While the aspirin reduced the risk for cardiovascular disease and colorectal cancer, among other cancers, the risk of gastrointestinal bleeding outweighed those benefits, creating more risks to the body. In a study of 33 people with severe osteoarthritis, pycnogenol (200 mg/day) reduced inflammatory markers after 3 weeks. This bark extract has been around for about 450 years. (2004). It also reduced the size of scars. Extracts can also be made from other pine barks, such as Pinus radiata, Pinus densiflora, Pinus thunbergii, and Pinus massoniana. Circulation and Jet Lag on Long Flights. Pycnogenol is a patented formulation of Pine Bark Extract which is standardized to 65-75% Procyanidin compounds by weight. Pine bark extract can make a great addition to your nutritional arsenal for its potent antioxidant support, as well as its added support for blood flow, blood sugar, inflammation, immunity, brain function and skin support. Patients were given 100 milligrams of Pycnogenol, a branded version of pine bark extract, for 12 weeks, with continued anti-diabetic treatment. But what makes this miracle ingredient so amazing? Researchers suggest that Pycnogenol may reduce cough, night-awakenings, improve airway flow, and the need for additional asthma medication [16]. A systematic review of 14 studies found that Pycnogenol gum or mouthwashes may reduce dental plaque, but the quality of evidence is low [58, 59]. There is currently insufficient evidence to determine what a safe and effective dose of lysine is for specific conditions. (2017). The dosage in most clinical studies varied between 50-360 mg/day. The effects of the pine bark extract showed significant lower levels of blood glucose and improved endothelial function when compared to placebo, concluding that supplementation of Pycnogenol for treating conventional diabetes may be beneficial. Pycnogenol has several benefits to your health and beauty. The antibacterial activity was assessed indicating that the essential oil of pine bark, specifically the proanthocyanidins, were effective against P. aeruginosa, significantly inhibiting its growth. Thirty patients with diabetic ulcers were treated with 150 mg Pycnogenol daily for four weeks and another group of 30 comparable patients received no treatment. This condition can be temporary or permanent however, some studies have indicated that pine bark extract may help alleviate these symptoms due to its high presence of antioxidants. Studies have shown that the tree bark can help decrease common symptoms including hot flashes, mood swings, irregular periods, and others. Pycnogenol supplementation reduced skin redness from UV rays in a trial of 21 people over 8 weeks. In the study, many of the participants on Pycnogenol reduced their dosage of high-blood-pressure medication (nifedipine) [37]. Start with a low dose so you can be sure it doesnt cause any side effects. (5). Results showed that one month of Pycnogenol led to a significant reduction of hyperactivity with improvement in attention and visual-motor coordination and concentration, as compared to no positive effects in the placebo group. The study showed that many people who participated had a drop in their systolic blood pressure after taking Pycnogenol. If you knew you could resolve your erectile dysfunction and, therefore, naturally remedy impotence issues, wouldnt you? The . Are there any risks to taking it? A study of 50 mildly infertile men found that a combination of L-arginine, L-citrulline, roburins, and Pycnogenol (Prelox R) may improve sperm quality, volume, and concentration [75].