Pityriasis rosea Gibert is an erythematous-papulosquamous dermatosis that frequently occurs in young adults. The site is secure. Some studies have identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike proteins on endothelial cells and lymphocytes from PR-like lesions, consistent with direct viral invasion (3, 4). The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). 2022 Jul 21;14(7):e27108. Following the national COVID-19 vaccination guidelines, she received a shot of ChAdOx1 nCoV-19 (AZD1222) vaccine before the therapy. Martora F, Battista T, Marasca C, Genco L, Fabbrocini G, Potestio L. Clin Cosmet Investig Dermatol. 2021 Sep;35(9):e546-e548. All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Cutaneous manifestation has been reported in 0.2% of patients infected by COVID-19 in China, and 18 out of 88 patients from Italy. "It looks very different.". Our experience with 80 cases of SARS-CoV-2-Clostridioides difficile co-infection: An observational study. 2022 Nov;36(11):1947-1968. doi: 10.1111/jdv.18294. MeSH J Eur Acad Dermatol Venereol. Dermatol Reports. Common causes of drug-induced PR-like eruptions include angiotensin-converting enzyme inhibitors, non-steroidal anti-inflammatory drugs, and gold. These findings were consistent with a diagnosis of PR-like eruption. Please enable it to take advantage of the complete set of features! 2021 Dec;108(6):317-318. doi: 10.12788/cutis.0411. It's also what's known as a self-limiting rash, Hartman says, in that it can resolve itself on its own without treatment in about six to eight weeks. Would you like email updates of new search results? Due to the temporal relationship between vaccination and onset of rash, COVID-19 vaccination was the most likely etiology. Epub 2021 May 29. Dermatol Ther. 2021 Oct;20(10):3080-3084. doi: 10.1111/jocd.14372. doi: 10.1016/j.jaad.2021.03.092, 15. A few days later, the cluster came: Ten little dots arranged themselves in a perfect alien-like crop circle on my upper back, and they itched so much that I scratched them raw. There isnt a cure, but it isnt contagious. 2022 Nov 6;15:2369-2382. doi: 10.2147/CCID.S388245. Cutaneous Reactions Following COVID-19 Vaccination: A Review of the Current Literature. . JAAD Case Rep. 2021;7:9394. Few brownish patches also appeared, suggestive of post-inflammatory hyperpigmentation. Unable to load your collection due to an error, Unable to load your delegates due to an error. J Investig Dermatol 2005;124:123440. 2021 Jun 25;118(25):431. doi: 10.3238/arztebl.m2021.0257. Pityriasis means scaly, and rosea means pink, but the rashes may look red, gray, brown or purple. In: Knoop KJ, Stack LB, Storrow AB, et al., eds. The patient had a positive RT-PCR result, and was confirmed with SARS-CoV-2 infection. 2022 Nov 1;43(6):555-558. doi: 10.2500/aap.2022.43.220058. The .gov means its official. Medicines (Basel). PMC We present two cases of COVID-19 vaccine-induced pityriasis rosea. Lessons: This site needs JavaScript to work properly. 7 Articles, This article is part of the Research Topic, Creative Commons Attribution License (CC BY), Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. Pityriasis rosea: An update on etiopathogenesis and management of difficult aspects. Would you like email updates of new search results? Various mild and benign cutaneous manifestations of the different forms of the COVID-19 vaccine have been documented. Rare Heterogeneous Adverse Events Associated with mRNA-Based COVID-19 Vaccines: A Systematic Review. ", The 29 Best Valentines Day Gifts for the Men in Your Life. Bethesda, MD 20894, Web Policies McMahon DE, Amerson E, Rosenbach M, Lipoff JB, Moustafa D, Tyagi A, Desai SR, French LE, Lim HW, Thiers BH, Hruza GJ, Blumenthal KG, Fox LP, Freeman EE. Unauthorized use of these marks is strictly prohibited. Oily fish, such as mackerel, salmon or sardines. PMC While it can spread all over the entire body, PR usually favors the trunk, says Christina Lam, an assistant professor of dermatology at Boston University School of Medicine and dermatologist at Boston Medical Center. Unable to load your collection due to an error, Unable to load your delegates due to an error. Vote for your favorite beauty products now! While home remedies are safe for most people, its a good idea to check with your healthcare provider before trying some of the following options. Global prevalence and clinical manifestations of cutaneous adverse reactions following COVID-19 vaccination: A systematic review and meta-analysis. Factors affecting the severity of central centrifugal cicatricial alopecia. FOIA Epub 2022 Jan 31. Drago F, Ciccarese G, Rebora A, et al. Cebeci Kahraman F, Sava Erdoan S, Akta ND, Albayrak H, Trkmen D, Borlu M, Arca DA, Demirba A, Akbayrak A, Polat Ekinci A, Gkek GE, elik HA, Taolar MK, An , Temiz SA, Hazinedar E, Ayhan E, Hzl P, Solak E, Kl A, Ylmaz E. J Cosmet Dermatol. (2017) 5:20311. Learning points: JAAD Int. Polack FP, Thomas SJ, Kitchin N, et al. Unable to load your collection due to an error, Unable to load your delegates due to an error. Dermatology. "Any type of stress on the body can sometimes [cause them, and] any vaccine, not just the COVID one.". Epub 2022 Jun 19. Pityriasis lichenoides has distinct acute and chronic forms, which are usually distinct . Bookshelf How quickly did it come on, and did my boyfriend also have it? User Agreement and Privacy Policy and Cookie Statement and Pityriasis rosea after mRNA COVID-19 vaccination Pityriasis rosea after mRNA COVID-19 vaccination Pityriasis rosea after mRNA COVID-19 vaccination Pityriasis rosea after mRNA COVID-19 vaccination Int J Dermatol. Lasers Med Sci. Epub 2021 Jun 10. Sprinkle bath water with an oatmeal-based bath product (Aveeno). The https:// ensures that you are connecting to the 2021;185(2):e34. A woman. Even though it is benign, it can cause substantial. Pityriasis Rosea Following Pfizer-BioNTech Vaccination in an Adolescent Girl. Figure 3. I tell my patient to use a gentle non-soap cleanser." Front. Authors Lina Abdullah 1 This article presents a case of PR in a 66-year-old black male 1 week after administration of the Pfizer-BioNTech COVID-19 vaccine. Federal government websites often end in .gov or .mil. J Eur Acad Dermatol Venereol. 2021 Dec;108(6):317-318. doi: 10.12788/cutis.0411. (2021) 35:e5468. Federal government websites often end in .gov or .mil. PMC See this image and copyright information in PMC. Careers. It is increasingly recognized that SARS-CoV-2 infection and COVID-19 vaccines have been associated with skin disorders, including pityriasis rosea. -, Welsh E, Cardenas-de la Garza JA, Cuellar-Barboza A, Franco-Marquez R, Arvizu-Rivera RI. Safety and efficacy of the BNT162b2 mRNA Covid19 vaccine. Pearls and pitfalls: Adverse cutaneous reactions after COVID-19 vaccination. The .gov means its official. Epub 2021 Aug 26. Would you like email updates of new search results? Epub 2022 Jan 5. Unable to load your collection due to an error, Unable to load your delegates due to an error. Histopathologic features: (B) microscopic image at a low power field showing psoriasiform epidermal hyperplasia, perivascular infiltration, and interface dermatitis (hematoxylin-eosin; scale bar represents 100 m); (C) microscopic image at a high power field showing focal spongiotic dermatitis, interface dermatitis, and perivascular infiltration of lymphocytes and eosinophils (hematoxylin-eosin; scale bar represents 40 m). Global prevalence and clinical manifestations of cutaneous adverse reactions following COVID-19 vaccination: A systematic review and meta-analysis. Drago F, Ciccarese G, Rebora A, Parodi A. (b) haematoxylineosin, original magnification 20. J Am Acad Dermatol. Some people develop a few large patches on their skin. (2017) 9:7399. doi: 10.4081/dr.2017.7399, 17. They were found on hands and feet, showing up as red or purple spots caused by bleeding under the skin. Federal government websites often end in .gov or .mil. 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event. Pityriasis rosea-like eruption after Pfizer-BioNTech COVID-19 vaccination. If you have pityriasis rosea, the rash with go away without treatment. Skin lesions appeared in a 49-year-old female 8 days after the first dose of the BNT162b2 mRNA vaccine and in a 53-year-old male 7 days after the second dose of the same vaccine. Dermatol Ther. -, Johansen M, Chisolm SS, Aspey LD, Brahmbhatt M. Pityriasis rosea in otherwise asymptomatic confirmed COVID-19-positive patients: a report of 2 cases. In conclusion, we have described the first case of PR-like eruption following ChAdOx1 nCoV-19 (Oxford/AstraZeneca) vaccination. These patches are smaller than the herald patch they range from 1 to 2 cm and are often called daughter patches. Your California Privacy Rights. National Library of Medicine If I dont have pityriasis rosea, what other skin condition might I have? Marcantonio-Santa Cruz OY, Vidal-Navarro A, Pesqu D, Gimnez-Arnau AM, Pujol RM, Martin-Ezquerra G. J Eur Acad Dermatol Venereol. 2021 Nov;35(11):e721-e722. The https:// ensures that you are connecting to the J Invest Dermatol. It was found on younger COVID-19 patients suffering milder forms of the virus. Keywords: Copyright 2021 Leerunyakul, Pakornphadungsit and Suchonwanit. In addition to a corticosteroid cream, New York City-based dermatologist Macrene Alexiades recommends keeping showers short and lukewarm, as "water, sweat, and soap reportedly irritate and inflame the lesions. Unauthorized use of these marks is strictly prohibited. Atypical pityriasis rosea associated with mRNA COVID19 vaccine E. Bostan, Adam Jarbou Published 29 September 2021 Medicine Journal of Medical Virology Variable dermatological manifestations including acral erythema, urticaria, vasculitis, vesicular or pustular eruptions, maculopapular rash have all been reported during the course of Covid-19. The Moderna and Pfizer-BioNTech COVID-19 vaccines are the first two COVID-19 vaccines authorized by the Food and Drug Administration for emergency use and already have been given to millions of Americans. The site is secure. A more recent letter in the International Journal of Dermatology reported a "unique case of pityriasis rosea following administration of mRNA COVID-19 vaccine." doi: 10.1111/bjd.20143. 2022 Nov 6;15:2369-2382. doi: 10.2147/CCID.S388245. Proc (Bayl Univ Med Cent). 2021;35(8):e489e491. (d) Patient 2: Closeup of plaques, with the hyperpigmented centre and trailing scale. Khalili M, Abtahi-Naeini B, Rastegarnasab F, Afshar K. Clin Case Rep. 2022 Jul 19;10(7):e6096. The typical distribution of the rash is on the trunk between the neck and the knees.". Suchonwanit P, Leerunyakul K, Kositkuljorn C. Cutaneous manifestations in COVID-19: Lessons learned from current evidence. PS conceptualized the case report and revised the manuscript. 2022 Aug;20(8):1123-1124. doi: 10.1111/ddg.14784. 2022 Jun;7:164-168. doi: 10.1016/j.jdin.2022.01.009. 2022 Oct;123:58-69. doi: 10.1016/j.ijid.2022.06.037. Laboratory investigation results (i.e., complete blood count, blood chemistry, C-reactive protein level, erythrocyte sedimentation rate, serological test for syphilis, plasma polymerase chain reaction (PCR) for human herpesvirus (HHV)-6 and HHV-7, and reverse transcription-PCR for COVID-19) were unremarkable. Of the 30 cases found, none experienced severe adverse effects and the rash resolved in an average of 5.6 weeks. The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author/s. Epub 2021 Apr 26. If you have pityriasis rosea, it can generally be well-managed without any treatment. Pityriasis rosea (pih-tuh-RY-uh-sis ROH-zee-uh) is a common skin condition that causes patches of your skin to develop raised, scaly rashes. Epub 2022 Jun 13. The authors suggest more research is necessary. retailers. Refined carbohydrates, such as sugar, pastries and white bread. An official website of the United States government. You may be more likely to develop it if youre: In some cases, people with pityriasis rosea report that they had significant or long-term stress before developing a rash. Conflicts of Interests: The authors declare there are no competing interests. Int J Infect Dis. The most commonly inoculated vaccines include those against smallpox, followed by tuberculosis, poliomyelitis, influenza, and human papillomavirus virus (12, 13). These strains of the herpes virus arent related to the strains that cause cold sores or genital herpes. J Am Acad Dermatol. Adya KA, Inamadar AC, Albadri W. Post Covid-19 vaccination papulovesicular pityriasis rosea-like eruption in a young male. For instance, the rash sometimes appears only under the arms or on the flanks. Your rash looks infected (red, purple, gray or white skin; irritation and swelling). Epub 2021 Aug 7. 2022 by the American Academy of Dermatology, Inc. doi: 10.1111/jdv.12942, 13. According to King, an in-person skin exam is usually enough to make an accurate diagnosis, though a biopsy or blood work may be necessary for some. -, Broccolo F, Drago F, Careddu AM, et al. I figured a very determined mosquito had snuck into my room and attacked me through my tank top. 1 Several vaccines have been developed to fight against COVID19, to prevent the transmission among susceptible individuals and to decrease the morbidity Bookshelf Disclaimer. "It's usually not from head to toe that's more atypical but there are some people that get it more in the groin area or in the armpit rather than on the trunk predominantly, which is just a variant.". Unfortunately, due to her deteriorating neurologic status, her associated symptoms were not evaluated properly. Histopathologic examination revealed epidermal focal spongiosis, interface dermatitis with necrotic keratinocytes, perivascular lymphocytic infiltration, and few eosinophilic infiltrations in the superficial dermis (Figures 3B,C). official website and that any information you provide is encrypted COVID-19; Vaccination; pityriasis rosea. SARS-CoV-2 spike protein positivity in pityriasis rosea-like and urticaria-like rashes of COVID-19. Shabazz DR. Pityriasis Rosea. It is likely that a new viral trigger of pityriasis rosea is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291919/). Pityriasis rosea (PR)-like eruption is a cutaneous complication associated with several medications and vaccinations. Temiz SA, Abdelmaksoud A, Dursun R, Durmaz K, Sadoughifar R, Hasan A. J Cosmet Dermatol. Pityriasis rosea following SARS-CoV-2 vaccination: A case series. -, Carballido Vzquez AM, Morgado B. Pityriasis rosea-like eruption after PfizerBioNTech COVID-19 vaccination. Herzum A, Trave I, D'Agostino F, Burlando M, Cozzani E, Parodi A. Clin Exp Vaccine Res. Epub 2021 May 29. We present a case of a pityriasis rosea-like rash occurring after Pfizer COVID-19 vaccination and review cases of pityriasis rosea (PR)/PR-like eruption (PR-LE) after mRNA COVID-19 vaccine published in the medical literature. (Within two days, and still no.) J Am Acad Dermatol. What at-home treatments do you recommend? Parakeratosis with minimal acanthosis and spongiosis of the epidermis. Pityriasis rosea (PR)-like eruption is a rare cutaneous complication of immunization. If you have pityriasis rosea, its unlikely that youll get it again. Epub 2022 Jul 19. doi: 10.7759/cureus.27108. Br J Dermatol. (a) Patient 1: Thin, Histopathological findings of pityriasis rosealike, Histopathological findings of pityriasis rosealike eruption in patient 1. A 52-year-old Thai woman with a one-year history of recurrent glioblastoma was admitted to our hospital for a planned targeted therapy. However, a fungus causes ringworm. National Library of Medicine The study said the appearance was similar to pityriasis rosea, a common skin condition. Dermatol Ther. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Epub 2020 Nov 20. eCollection 2022. J Eur Acad Dermatol Venereol 2020;34:e2123. Human herpesvirus6, 7, and EpsteinBarr virus reactivation in pityriasis rosea during COVID19. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Inverse pityriasis rosea secondary to COVID-19 vaccination. In addition to COVID-19 vaccination, she was currently taking medications (i.e., levetiracetam and thyroxin) for glioblastoma, and the two drugs had been prescribed for approximately nine months. The appearance of pityriasis rosea following the first injection of the AstraZeneca vector vaccine suggests a causal connection. American Academy of Dermatology's National Library of Dermatologic Teaching Slides. This patch is the herald or mother patch. Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: a registry-based study of 414 cases. However, after 14 days, she developed multiple discrete blanching erythematous oval patches and plaques on the lower abdomen, back, and bilateral upper thighs (Figures 1A,B). (No.) Received: 03 August 2021; Accepted: 17 August 2021; Published: 07 September 2021. Allure may earn a portion of sales from products that are purchased through our site as part of our Affiliate Partnerships with Most of the rare, severe allergic reactions to these vaccines have occurred in people with a history of allergies. Pityriasis rosea-like eruption presenting as multiple discrete erythematous oval patches and plaques on the back (A) lower abdomen, and bilateral upper thighs (B); lesions distributed along cleavage lines without prominent scales (C). Women and young people are most likely to have these reactions. Pityriasis Rosea Associated With COVID-19 Vaccination: A Common Rash Following Administration of a Novel Vaccine. The condition is more prevalent in spring and fall. 2022 Nov 6;15:2369-2382. doi: 10.2147/CCID.S388245. Like previously reported cutaneous eruptions associated with COVID-19 infection, these cases "raise more questions than . Pityriasis Rosea Shortly After mRNA-1273 COVID-19 Vaccination. Vaccinations have been identified to rarely cause several cutaneous reactions. McMahon DE, Amerson E, Rosenbach M, Lipoff JB, Moustafa D, Tyagi A, et al. -, Polack FP, Thomas SJ, Kitchin N et al. Your skin may develop discolored patches (lesions) that look like scales or dry, crinkly paper. Bethesda, MD 20894, Web Policies Despite this rare complication, our report highlights that the presence of PR-like eruption is not a contraindication for subsequent vaccinations. Few scattered dyskeratotic keratinocytes are seen in the lower epidermis. Adverse cutaneous reactions following COVID-19 vaccines have increased, highlighting not only how SARS-CoV-2 infection but also COVID-19 vaccines may induce adverse cutaneous manifestations. However, adverse effects to COVID-19 vaccines, particularly cutaneous reactions, have been reported. 2022 Sep;21(9):3692-3703. doi: 10.1111/jocd.15209. Why not? No use, distribution or reproduction is permitted which does not comply with these terms. Some treatments can alleviate related symptoms, including itching. Here, we report the first case of PR-like eruption following ChAdOx1 nCoV-19 (Oxford/AstraZeneca) vaccination. (2020) 33:e13878. (2016) 30:5445. ", Though there's no single-known cause, King says, "pityriasis rosea is associated with reactivation of herpesviruses 6 and 7 [HHV-6 and HHV-7, respectively], which cause the primary rash, roseola, in infants. 2022 May;11(2):222-225. doi: 10.7774/cevr.2022.11.2.222. Get useful, helpful and relevant health + wellness information. Epub 2021 Aug 7. and transmitted securely. Variable dermatological manifestations including acral erythema, urticaria, vasculitis, vesicular or pustular eruptions, maculopapular rash have all been reported during the course of COVID19. Histopathological Patterns of Cutaneous Adverse Reaction to Anti-SARS-CoV-2 Vaccines: The Integrative Role of Skin Biopsy. (2020) 33:e13650. Br J Dermatol. Children often get infected when someone sneezes or kisses them. J Am Acad Dermatol. doi: 10.1111/ijd.13061. Last reviewed by a Cleveland Clinic medical professional on 06/17/2022. Foods that have anti-inflammatory properties include: Foods that may increase inflammation include: There isnt any way to prevent pityriasis rosea. Rybak-d'Obyrn J, Placek W, Owczarczyk-Saczonek A, Derkaczew M, Joniec E, Hofman R, Stompr M. Clin Cosmet Investig Dermatol. A 3-cm oval plaque with peripheral scale, larger, MeSH Pityriasis rosea following SARS-CoV-2 vaccination: A case series. Cureus. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. 2022 May;121(5):1003-1007. doi: 10.1016/j.jfma.2021.12.028. COVID-19 has been reported as one such viral trigger for PR. Pityriasis Rosea. Pityriasis rosea is a common condition that causes discolored patches on your skin. (2016) 55:e33843. Before -, Cyrenne BM, Al-Mohammedi F, DeKoven JG, Alhusayen R. Pityriasis rosea-like eruptions following vaccination with BNT162b2 mRNA COVID-19 vaccine. We do not endorse non-Cleveland Clinic products or services. COVID-19; HHV, human herpes virus; Moderna; PR; PR, pityriasis rosea; PR-LE; PR-LE, pityriasis rosea-like eruption; Pfizer; coronavirus; dermatology; mRNA vaccine; mRNA, messenger RNA; pityriasis rosea; pityriasis rosealike eruption; vaccine. Allergy Asthma Proc. 2021 Sep;35 (9):e546-e548. Physical examination revealed that lesions were distributed along cleavage lines, similar to PR, without herald patch or prominent scales (Figure 1C). Advertising on our site helps support our mission. These types cannot cause cold sores or genital herpes. Cutis. JAAD Int. Patient concerns: doi: 10.1111/bjd.20143. 2022 Nov;36(11):1947-1968. doi: 10.1111/jdv.18294. Department of Dermatology, Graduate School of Medicine, Kyusyu University, Japan. Welsh E, Cardenas-de la Garza JA, Cuellar-Barboza A, et al. Involvement of the oral mucosa has also been reported in as many as 50% of all cases (11). HHS Vulnerability Disclosure, Help Medicine (Baltimore). As vaccine reactogenicity reports continue to surface, dermatologists and other health care providers should understand the landscape of the latest cutaneous reactions to guide and address patients' concerns. She diagnosed it as pityriasis rosea, a benign but frustratingly itchy rash that in her words just happens sometimes. About one to two weeks later, discolored circular or oval-shaped patches appear in groups near the herald patch. Pityriasis rosea is a benign inflammatory rash that starts with a single red rash, also known as the "herald patch," which eventually gives way to a larger, similar-looking rash on the trunk within days or weeks, says dermatologist Corey L. Hartman, founder of Skin Wellness Dermatology in Birmingham, Alabama. "There's some emerging data where there are certain skin rashes that seem to be more associated with the COVID vaccine, and pityriasis rosea is one them. Br J Dermatol 2021. Among patients who received inactivated vaccines, another case of PR-like eruption was reported four days after the first dose of CoronaVac (SinoVac) (1).