Intradermal allergy testing is the gold standard for this and involves a veterinary dermatologist subcutaneously injecting very small quantities of potential allergens into a clipped patch of the horses neck. Long-term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy and quality of life. I hear the result have been spectacular. 3. Apoquel can be administered to dogs over the age of 12 months for 14 days, during which the veterinarian would most likely decrease the dose to once a day. Renal Anemia, or . Sometimes it goes overboard and reacts in the face of a generally harmless substancewhich the body begins to recognize as an allergenand an allergic reaction occurs. When your dog is itchy, you get desperate to make him feel more comfortable. Speak to yourveterinarian in an emergency. She still has her mane this year- which is good! Apoquel is not FDA approved to use twice daily longer than 14 days. How Organized Are Your Horses Health Records? Ordering patient medications is easy. In some dogs, this can be overcome by splitting the total daily dose in half and give twice daily. Fukuyama T, Ganchingco JR, Bumer W. Demonstration of rebound phenomenon following abrupt withdrawal of the JAK1 inhibitor oclacitinib. Apoquel is an anti-allergy drug that's often prescribed by vets. The dose of APOQUEL (oclacitinib maleate) tablets is 0.18 to 0.27 mg oclacitinib/lb (0.4 to 0.6 mg oclacitinib/kg) body weight, administered orally, twice daily for up . Apoquel is the #1 prescribed medicine for fast, effective relief of allergic itch and inflammation due to atopic and allergic dermatitis 1 Indications Control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age. We recommend Platinum Skin and Allergy or Aleira. Assuming you cannot contact your vet: For hives or possible allergic airway disease (heaves), for a 1000 lb horse, give 5-10 tabs of 25mg diphenydramine crushed up and mixed in water and dosed in a syringe orally (by mouth). Rosenkrantz WS, Bourgeois AS. APOQUEL may be administered with or without food. More severe ones, however, can truly take a toll on your horses health and make him miserable. On the topic of simple and economical allergy management, a readily accessible ingredient that helps many horses is flaxseed. 23. Simpson AC, Schissler JR, Rosychuk RAW, et al. Cochet Faivre N, Degorce-Rubiales F. Clinical eosinophilic popular dermatitis associated with histological eosinophilic granuloma rapidly responsive to oclacitinib in an adult Labrador retriever. Dosage and administration For oral use. Read on below! Apoquel has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporines. Since oclacitinib has been shown to be comparable to prednisolone, oclacitinib can be a good alternative to prednisolone when combined with cyclosporine for initial treatment. With a prescription number, easily refill prescriptions and enroll in the AutoRefill Program. Dosage and treatment schedule The recommended initial dose is 0.4 to 0.6 mg oclacitinib/kg bodyweight, administered orally, twice daily for up to 14 days. In the past 5 years, however, oclacitinib (Apoquel; zoetisus.com), a Janus kinase (JAK) inhibitor, has become another important drug in the management of allergic pruritus. 17. During this period, the drug is administered twice daily, with an interval of 12 hours. FALL 2019. m. Editor: Norma White-Weithers, MS, DVM, DACVD Veterinary Allergy & Dematology Consultant, Baldwin, NY 11510 Work: 646-329-4719 . Simple strategies for dust reduction include removing the horses from the stalls when mucking out and blowing the aisle or ditching the leaf blower altogether, Fultz says. To overcome its delayed effect, cyclosporine is often initially combined with other drugs such as prednisolone to accelerate the anti-inflammatory and antipruritic effects. Allergies are generally managed based on the severity of clinical signs. Rabies in Animals. I paid $250 for 100 pills (thats 20 5-pill doses). While efficacy was comparable to that observed in the previous studies, significant positive effects on the dogs quality of life were observed in >91.5% of cases after 630 days. . Commonly prescribed for: Manage inflammation in diseases or conditions in which the immune system has a significant role, Therapeutic Class: Synthetic Corticosteroid Hormone. She has a master's degree in animal science from the University of Delaware and graduated from the University of Pennsylvania School of Veterinary Medicine in 1982. Vet Dermatol 2015;26(3):171-179, e35. Some states restrict the information we may provide about controlled substances. Treatment will probably need to repeated somewhere between 1 and 6 weeks after the initial treatment course. Efficacy of oclacitinib (Apoquel) compared with prednisolone for the control of pruritus and clinical signs associated with allergic dermatitis in client-owned dogs in Australia. Some dogs exhibit increased pruritus when the dosage is reduced to once daily. This might, down the road, be an easier and less expensive alternative for horse owners. A blinded, randomized clinical trial comparing the efficacy and safety of oclacitinib and ciclosporin for the control of atopic dermatitis in client-owned dogs. Avoid giving the medicine twice daily long-term. The frequency of urinary tract infection and subclinical bacteriuria in dogs with allergic dermatitis treated with oclacitinib: a prospective study. Most commonly, horses develop an allergy to the saliva of biting insects (e.g., gnats, black flies, stable flies, horn flies) known as, While relatively safe for use in most horses, these potent anti-inflammatory drugs can cause a serious potential side effect in some individuals: an increased risk of developing the debilitating hoof disease. Before your vet administers immunotherapy, though, you must identify your horses respiratory and skin allergies. In fact, in our. Apoquel has been used safely with many common medications including parasiticides, antibiotics and vaccines. She adds, however, that some horses allergy signs are so dramatic that corticosteroids are the most logical choice, at least initially. Do not use Apoquel in dogs less than 12 months of age or those with serious infections. When working with a liquid: Multiply your horse's weight in pounds times the dose rate in milligrams per pound. Successful treatment of atopic dermatitis with the JAK1 inhibitor oclacitinib. A horse can hypothetically be allergic to anything he touches, inhales, ingests, or has applied to or injected into his body. Saridomichelakis MN, Olivry T. An update on the treatment of canine atopic dermatitis. We can let your veterinarian know that you are interested in our compounded Dexamethasone. Apoquel is a non-hormonal drug for dogs, used for dermatitis of various etiologies, which are accompanied by itching. She adds, however, that some horses allergy signs are so dramatic that corticosteroids are the most logical choice, at least initially. Since the vast majority of Equine Asthma patients do not have a histamine-associated problem, this isn't likely to work for most. However, a small subcategory of asthmatic horses suffer from pasture-associated equine asthma. Haugh IM, Watson IT, Menter MA. Vercelli A, Cornegliani L. Use of oclacitinib in treatment of canine idiopathic ear tip vasculitis. Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis. Apoquel Dosage. Researchers have proven flaxseed reduces skin lesions in IBH horses (ONeill et al., 2002). This product is a hand-held device that administers an anti-inflammatory mist into the horses nostril. 11. The most common practical starting dosage for many cats is of the 5.4mg tablet, or 2.7mg. There are 4 JAK families in mammals: JAK1, JAK2, JAK3, and TYK2. Oclacitinib preferably inhibits JAK1 and, to a lesser degree, JAK3, resulting in decreased activity of JAK1-dependent cytokines involved in allergy and inflammation (IL-2, IL-4, IL-6, and IL-13) as well as pruritus (IL-31). This drug has been used in dogs with some pretty fabulous results. 4. For more information, please see the full Prescribing Information. More severe ones, however, can truly take a toll on your horses health and make him miserable. For years, glucocorticoids and cyclosporine have been used for the symptomatic management of atopic dermatitis, including the associated pruritus. Most common side effects are vomiting and diarrhea. Allergies primarily affect the immune, respiratory, and integumentary (skin) systems and, if unmanaged, can seriously impact an animals performance and well-being. 13. But I had my mare tested last year, she also came up allergic to some foods (flax being one) for which I was told serum was not an option. 23. The dosage for dogs 10-14.9 lbs is of a 5.4 mg tablet twice daily. Vet Dermatol New neoplastic conditions (benign and malignant) were observed in clinical studies and post-approval. Option 1 is the cheap/easy route, but comes with risks. Apoquel (oclacitinib tablet) Dosing & Administration How to dose Apoquel 0.4-0.6 mg/kg (0.18-0.27 mg/lb) Twice daily (BID) for up to 14 days Continue therapy once daily (SID) thereafter for maintenance May be given with or without food May discontinue without tapering Apoquel Dosing Guide Weight Range (lb) Number of Tablets to be Administered The dosages of oclacitinib of 1 mg/kg and 2 mg/kg were chosen because the dosages used for dogs (0.4-0.6 mg/kg) were not shown to be very effective in cats [ 18 ], and the higher dosage range of 0.8-1.3 appeared to be more effective in allergic cats [ 22 ]. I had a cat on it years ago and it was $$$$ but it was the only thing that worked for her. 29. 11. Vet Dermatol 2016;27(Suppl 1):84 (abstract). Option 3 is using a nebulizer with dexamethasone and/or other drugs. 27. Currently, White is part of a team evaluating the possibility of delivering allergy shots in the form of a juice squirted under the horses tongue. Gadeyne C, Little P, King VL, et al. Log in to browse, order and prescribe from our compounded drugs formulary. While easy to perform, Fultz says its not always accurate at predicting the exact allergens. Since it became available in 2014, several clinical studies have confirmed its antipruritic effect not only in dogs but also in cats, as well as in other immune-mediated diseases. 2022 Zoetis Services LLC. Allergies can develop at any time, in any horse, and seemingly for any reason. May be used with other common medications. Transdermal applicator designed for easy handling and accurate dosing. On the label for dogs, Apoquel is used every 12 hours for the first 14 days of use, then backed down to dosing every 24 hours once a day. My dog has been on apoquel for about 2 years. One of the things the trials found on using apoquel with horses is that they need a relatively small dose. A follow-up study assessed the long-term safety, efficacy, and quality of life of oclacitinib-treated dogs. These and other kinase-inhibiting drugs sometimes work very well to stop the itching. Most commonly, immunotherapy involves injecting gradually increasing doses of a specific allergen subcutaneously (just under the skin), explains White. If your horse's test results (from a BAL or tracheal wash) show a certain cell type in the lungs, we may recommend trying Zyrtec!Clenbuterol: This is a bronchodilator that may be beneficial in treating some horses with Equine Asthma. Banovic F, Tarigo J, Gordon H, et al. Pasture-associated equine asthma is most prevalent during the summer in the southeastern U.S. but has been reported worldwide. Apoquel Overdose Information Dogs that received overdoses in safety studies had side effects that included one or more of the following: vomiting, diarrhea, cysts between the toes, skin inflammation, papilloma's (warts), pneumonia, enlarged lymph nodes, and decreased blood cell production. Clenbuterol dilates the airways, and may improve air flow, but it doesn't treat the inflammation associated with the disease. Pollen and other plant-based aeroallergens are the source of their distress, and they fare much better inside a well-ventilated barn. A blinded, randomized, placebo-controlled trial of the efficacy and safety of the Janus kinase inhibitor oclacitinib (Apoquel) in client-owned dogs with atopic dermatitis. This is a new treatment option, and currently the tablets are not FDA approved for horses, only dogs. Use of them does not imply any affiliation with or endorsement by them. Pros and cons of oclacitinib therapy. 1800PetMeds is your online pet store offering discount prices on pet supplies, medications, vitamins and supplements for your pet. Therefore, it is recommended that dogs 6.6-9.9 lbs take of a 3.6 mg tablet twice daily as an initial dosage. No claims are made as to the safety or efficacy of mentioned preparations. Dosage and Administration: The dose of APOQUEL (oclacitinib maleate) tablets is 0.18 to 0.27 mg oclacitinib/lb (0.4 to 0.6 mg oclacitinib/kg) body weight, administered orally, twice daily for up to 14 days, and then administered once daily for maintenance therapy. 6. I am not saying it is a cure all, but that and some generic Zyrtec make my mare a whole lot more comfortable. For atopic and allergic dermatitis, Apoquel may be given to dogs at a dosage of 0.18 - 0.27 mg/lb. Webcast | Quartering tablets is extra-label use. All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted. EHV Quarantine Released at Turf Paradise Racetrack, Six Simple Spring Safeguards for Senior Horses, Evaluating the Suspensory Ligament in Cutting Horses, Regular Dental Care Important in Horses Worldwide, Investigating Equine Cases of Toxicant Exposure, Podotrochlosis: Navicular is No Longer the End of the Road for Horses. We have limited her exposure to the type of grass that she is most allergic to (bermuda), but it is hard to actually remove her exposure to her allergens entirely. Gadeyne et al compared prednisolone and oclacitinib at recommended doses and found that both drugs resulted in similar rapid effects with regard to pruritus and dermatitis reduction. Vomiting, diarrhea, and lack of appetite are also possible. 21. has been administered by veterinarians to help horses of . No texts please., Horse breeding from planning through foal care, Horse-health-problem risk factors, prevention, diagnosis, and treatment, Design and maintain a healthy horse operation, Prevention and treatment for problems of the equine foot, How to care for the basic health needs of horses, Prevention, diagnosis, and treatment of leg lameness, Proper feeding practices for foals, adult horses, and older horses, All aspects of caring for performance horses, News and issues for equine health professionals, Discussions about the welfare of our equine friends. However, a small subcategory of asthmatic horses suffer from pasture-associated equine asthma. Uses for Apoquel This links to a pdf file Storage and Handling : Store at controlled room temperature 20 to 25C (68 . Vet Dermatol 2013;24:48-e12. Allergies are generally managed based on the severity of clinical signs. However, these studies have shown that oclacitinib can be a good alternative therapy to treat feline pruritus, especially for patients that do not respond to other treatments or do not tolerate steroids. to 14 days, and then administered once daily for maintenance therapy. 28. Im glad that youve found a solution- but, after the allergy testing you can start them on a regimen designed exactly for what they are allergic to, which will help to desensitize them to those allergens. Dosing Chart Warnings It is important to address that the use of oclacitinib in cats is off-label, and owners should be informed before using oclacitinib in this species. To ensure that it's easy to administer the proper dosage to your dog, this treatment comes in three different dosages. Atopic dermatitis is often a complex disease that requires a multifaceted approach. Oclacitinib maleate is used twice daily for two weeks and then dropped to a maintenance dose of once daily. We have had variable results with this treatmet. Avoid storing hay in the same barn as sensitive horses, since hay particles and spores can be irritating, even from a distance and even if they are not visible in the air. Repeated oral dose tolerance in dogs treated concomitantly with ciclosporin and oclacitinib for three weeks. Vet Dermatol 2015;26:297 (abstract). She is a New-York-based freelance author with a passion for equine health and veterinary care. 3. Vet Dermatol 2015;26(4):235-e52. Topical suspension administered in the ear. 13. Cats have been reported to drink more water while receiving this drug and also experience be- havior changes while receiving hydroxyzine. Right now he is on an Aservo Inhaler but I dont see any improvement and he is getting real tired of the application process. Log in to fill, refill or renew the medication prescribed by your veterinarian. Im not dealing with food allergies but both the company and the vet did not recommend allergy shots for my mare. In many cases, symptomatic therapy alone with drugs such as oclacitinib is insufficient to control allergies long-term. The results are problematic. At that point, the treatment can be changed to oclacitinib. If you mix it in their food, ensure that your pet chews the treatment rather than swallowing it without chewing for effective results. Meaning, if a 100lbs dog gets 16mg (1 pill), a horse does not need 160mg (10 pills). In this study, 70% of the study population receiving oclacitinib showed improvement in pruritus compared with 75% in a group receiving methylprednisolone.18 Based on this study, a higher dose with a longer induction period seems to be the key to successfully treating feline pruritus with oclacitinib. Search term . Pros and cons of oclacitinib therapy. After remission, some dogs were well controlled with a tapered dose of oclacitinib (0.2 to 0.5 mg/kg q24h), but some needed a higher dose (0.6 to 0.7 mg/kg q12h) to avoid relapse.28,29 The exact mechanisms of oclacitinib in these diseases are unknown; however, the need for daily administration of oclacitinib indefinitely to control the disease suggests that oclacitinib plays a role in controlling the disease. 8. Freedom of Information Summary NADA 141-345 Rosenkrantz WS, Bourgeois AS. 26. Then reintroduce each, one by one, while monitoring for hives or other signs of allergies. 29. Transdermal applicator that gives easy & accurate dosing every time. The most common side effect is lethargy, dry mouth, and urinary retention. Unlike steroids, the drug has minimal impact on the immune system. Old fashioned drugs like Benadryl and steroids don't work well any more. 5. Treatment success in three Andean bears (Tremarctos ornatus) with alopecia syndrome using Oclacitinib maleate (Apoquel). This content is intended for counseling purposes only. APQ-01043R3, halved to ensure that the ingredients are equally distributed. But Im not sure how much the long term cost will be yet. A blinded, randomized, placebo-controlled trial of the safety of oclacitinib in cats. Oclacitinib should not be given in dogs younger than 12 months of age due to an increased risk for activating demodicosis, bacterial pneumonia, and other serious infections. My mare started on 5 pills every day and then we were able to move her down to 5 pills every other day. This product is top-dressed onto the feed and helps horses with equine asthma, including heaves in older horses and inflammatory airway disease in young, athletic horses.". Table of Contents hide Apoquel dosage for dogs chart Apoquel for Dogs Reviews: Does It Really Work? When your dog (cat, horse, child) reacts violently to everyday things like; flea saliva (even from one solitary flea) . After completing a doctorate thesis and a rotating internship at the University of Zurich, Switzerland, he moved to the United States, where he completed a 3-year veterinary dermatology residency at the University of Georgia in 2004. 15. The drug targets pro-inflammatory proteins, called cytokines, responsible for itching and inflammation, relieving signs of skin allergies. Ive used it on a couple of mine, and I also have some friends who have done it. Administer it orally in the mouth of the or mix it in the dog food. Weve also been able to start rehabbing back into work. See how Apoquel works differently from steroids and cyclosporines, Discover how Apoquel can relieve allergic itch through an 8-week food trial, Hear from your peers about why Apoquel is their first choice for allergic itch relief, Explore the United States of Apoquel to see how Apoquel has benefited veterinarians in your region, Hear real stories of allergic itch relief from pet owners, See how Zoetis Petcare Rewards can benefit your practice, Informational resources for you to download and utilize within your practice, Provide additional information about Apoquel to pet owners with these resources, Continue therapy once daily (SID) thereafter for maintenance. Vet Dermatol 2019;30(1):17-e6. 30. Little PR, King VL, Davis KR, et al. Alternatively, your veterinarian may be able to show you some techniques. As the only FDA-approved equine PSGAG (polysulfated glycosaminoglycan) for degenerative joint disease (DJD) in horses, Adequan i.m. She has been allergy tested! The dose of APOQUEL (oclacitinib maleate) tablets is 0.18 to 0.27 mg oclacitinib/lb (0.4 to 0.6 mg oclacitinib/kg) body weight, administered orally, twice daily for up to 14 days, and then administered once daily for maintenance therapy. This includes dietary supplements, shampoos, liniments, fly sprays, coat conditioners, etc. Maximizing ventilation when horses are stalled and bedding with low-dust options such as wood byproducts; Purchasing dust- or mold-free hay and wetting, soaking, or steaming it prior to feeding to reduce inhaled particles; and Offering an alternative feed than hay for low-dust options. It is initially prescribed twice daily for 14 days, then once daily for maintenance therapy. That was 5-6 years ago now. Because its essentially impossible to predict these events, its important to keep records of your horses previous reactions and communicate them to your veterinarian. As a result, muscles relax and cause heavy sedation, notes DailyMed. Vet Dermatol 2015;26(1):23-30, e7-8. Gonzales AJ, Humphrey WR, Messamore JE, et al. Intradermal allergy testing is the gold standard for this and involves a veterinary dermatologist subcutaneously injecting very small quantities of potential allergens into a clipped patch of the horses neck. Generally self-limiting and harmless, hives are nonetheless uncomfortable and can occasionally lead to angioedema (swelling under the skin) or purpura (blood vessels rupturing and leaking blood internally). Avoiding Allergies . Frank RK, Galvan BA, Schoell AR, et al. A newer prescription drug, Apoquel (oclacitinib) has recently hit the market and might prove useful for allergic horses. Oclacitinib (APOQUEL) is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. Stay on top of the most recent Horse Health news with, If interested in adopting this horse, please submit an Adoption Inquiry via our website: Allaboutequine dot org. The biggest disadvantages are the cost, the need to acclimate the horse to having the device placed in his or her nostril, poor tolerance by some horses who dislike the device, and the uncertainty about how long your horse will be able to go without repeating the treatment. APOQUEL tablets may be administered with or without food. Rarely, dogs on Apoquel develop new skin masses; however, a long-term study found no association between Apoquel and the development of malignant cancer. Previcox is an FDA-approved non-steroidal anti-inflammatory (NSAID) prescription medication used in dogs to treat pain and inflammation associated with osteoarthritis and for the control of postoperative pain and inflammation associated with soft-tissue and orthopedic surgery. Veterinarians dose Apoquel at 0.18-0.27mg per pound of bodyweight. Equine Regenerative Therapies for Managing Arthritis in Horses, Infographic | 12 Smart At-Home Biosecurity Practices for Horse Owners, Infographic | How To Keep Your Horses Joints Healthy. on various factors. Urticaria (hives) is the most widely reported presentation of a skin allergy. The dose of Apoquel tablets is 0.18-0.27 mg/lb (0.4-0.6 mg/kg). 1. However, the twice-daily use must not last for more than 14 days. Vercelli A, Cornegliani L. Use of oclacitinib in treatment of canine idiopathic ear tip vasculitis. Rectal Prolapse in Dogs and Cats. Fultz adds that over time this process teaches the immune system to tolerate exposure to substances it previously considered irritating. Soaking hay can be time-consuming but is vital to helping horses that are showing signs of respiratory allergy., Feeding hay at ground level offers an added benefit: To maximize respiratory health, horses should spend portions of the day with their heads down, the way nature intended, she adds. 8. 1. Cost for the initial course of treatment (about 12 days) will be around $300-400. For this first stretch, thats not going to get me too far since I need the loading dose up front. The efficacy and safety of oclacitinib have been assessed in various studies. Vet Dermatol 2019;30(2):87-90. It is no surprise we see this omega-3-rich plant with anti-inflammatory and antioxidative properties in many skin and allergy supplements. While efficacy was comparable to that observed in the previous studies, significant positive effects on the dogs quality of life were observed in >91.5% of cases after 630 days. Rest assured, your horses are receiving the best possible disease protection. Diphenhydramine can alter the results of skin allergy testing; discontinue this medication at least 2 weeks before testing. Horse dosing is 5 pills. They result in the production of antibodies that block the allergy-causing IgE from recognizing the allergen, thus preventing the associated symptoms.. Powered by Discourse, best viewed with JavaScript enabled. Genome Biol 2004;5(12):253. If the horse is allergic to any of them, his immune system elicits a response, and a hive forms at the injection site. While this is a very important strategy for some types of Equine Asthma ("classic" RAO), it may not be as important when managing those with Summer-Pasture-Associated disease. I spend $150 a month on my horse on apoquel. Recently, researchers have delved into the causes and consequences of what now falls under the umbrella term equine asthma. 20. This is interesting. Once you have the horse's symptoms under control, you can try re-introducing hay. Most recently, it was suggested that the treatment strategy for canine atopic dermatitis might need to be adjusted. And some can got a lower dose or a further spread out dose. Simpson AC, Schissler JR, Rosychuk RAW, et al. Many allergic reactions are evident as a mild case of transient hives. In the first 2 randomized, double-blinded, placebo-controlled clinical trials, it was shown that oclacitinib, given at a dose of 0.4 to 0.6 mg/kg q12h, induced a rapid reduction in pruritus and treatment success in 62.3% to 67% of treated cases within 7 to 14 days. A newer prescription drug, Apoquel (oclacitinib) has recently hit the market and might prove useful for allergic horses. Meaning, if a 100lbs dog gets 16mg (1 pill), a horse does not need 160mg (10 pills). The dose of Apoquel is 0.4-0.6 mg/kg every 12 hours for up to 14 days, then 0.4-0.6 mg/kg once daily thereafter. For dogs weighing between 10 and 14.9 pounds, give of a 5.4 mg tablet twice daily as dosage. Loft K, Simon B. Discount Prices on Pet Supplies, Nexgard, Bravecto, Trifexis, Simparica TRIO, Apoquel, and more. Many allergens can cause skin reactions. Consider the risks and benefits of treatment in dogs with a history of recurrence of these conditions. She then completed a 1-year rotating small animal internship in Massachusetts followed by a 3-year veterinary dermatology residency in Georgia. This study showed that pruritus was improved in only 42% of the study population; thus, use of oclacitinib in cats did not seem to be as effective as in dogs. Pulsoni D, Freire A, Ferreira DR. Juvenile-onset ischemic dermatopathy in two dogs treated with oclacitinib. For the first two weeks, this is to be given twice per day, and then once per day after the first two weeks for maintenance. Apoquel Dosage for Dogs. 25. Cosgrove SB, Wren JA, Cleaver DM, et al. Why Do Some Horses Develop Respiratory EHV-1 and Others EHM? Acupuncture: It appears that some horses with Equine Asthma can benefit from acupuncture to help with breathing function. Gadeyne C, Little P, King VL, et al. Pruritus is a common clinical sign in allergic skin diseases. One of my horses was tested at New Bolton (he has since passed away) and I was told that a serum wasnt possible or effective for most of his food-bourne allergies. Ordering your pet's prescription drugs from Wedgewood Pharmacy is safe, and convenient. Vet Dermatol 2014;25(6):512-518. And I am debating spreading even further to every 2 days to see how she does, but I am a bit nervous to do so, especially when its so hot. 27. Apoquel starts working within 4 hours of administering the first dose and controls itching within 24 hours.