Gynecol.Oncol 2012;124(3):417-425. [The impact of L-carnitine administration on the serum level of myocardium injury markers in patients with acute carbon monoxide poisoning]. View abstract. Bella R, Biondi R, Raffaele R, Pennisi G. Effect of acetyl-L-carnitine on geriatric patients suffering from dysthymic disorders. Acetyl-L-carnitine in the treatment of mildly demented elderly patients. Nutr J. Lancet 10-14-1978;2(8094):805-807. 2010;54(1):37-44. Genger, H., Enzelsberger, H., and Salzer, H. [Carnitine in therapy of placental insufficiency--initial experiences]. View abstract. View abstract. View abstract. Eur J Appl Physiol Occup.Physiol 1990;60(1):1-6. Nutr Res 1997;17:405-414. Current issues regarding treatment of mitochondrial fatty acid oxidation disorders. View abstract. View abstract. Association of L- carnitine, propafenone and mexiletine]. Sproule, D. M., Dyme, J., Coku, J., de, Vinck D., Rosenzweig, E., Chung, W. K., and De Vivo, D. C. Pulmonary artery hypertension in a child with MELAS due to a point mutation of the mitochondrial tRNA((Leu)) gene (m.3243A > G). Prev Nutr Food Sci 2020;25(2):124-32. View abstract. J Inherit.Metab Dis 2009;32(4):488-497. View abstract. By naturally getting rid of brain fog while assisting with problematic insomnia issues, N-Acetyl-L-Carnitine is the optimal inclusion in the ProMind Complex formula that will also enhance energy . J Androl 2004;25(5):761-770. Madeddu, C., Dessi, M., Panzone, F., Serpe, R., Antoni, G., Cau, M. C., Montaldo, L., Mela, Q., Mura, M., Astara, G., Tanca, F. M., Maccio, A., and Mantovani, G. Randomized phase III clinical trial of a combined treatment with carnitine + celecoxib +/- megestrol acetate for patients with cancer-related anorexia/cachexia syndrome. View abstract. Samimi M, Jamilian M, Ebrahimi FA, Rahimi M, Tajbakhsh B, Asemi Z. Vascular Surgery 1991;25(8):607-617. Anti-human immunodeficiency virus (HIV) activitiy, safety, and pharmacokinetics of adefovir dipivoxyl (9-[2-(bis-pivaloyloxymethyl)-phosphonylmethoxyethyl]adenine) in HIV-infected patients. Cell Biochem.Funct. View abstract. Drug Dev Res 1988;14:213-216. 2007;52(6):1768-1774. Zhonghua Nan.Ke.Xue. Dealberto, M. J. Valproate-induced hyperammonaemic encephalopathy: review of 14 cases in the psychiatric setting. Corbucci, G. G., Melis, A., Piga, M., Marchionni, A., and Calvani, M. Influence of acetyl-carnitine on some mitochondrial enzymic activities in the human cerebral tissue in conditions of acute hypoxia. View abstract. View abstract. Am J Kidney Dis 1998;32(2):265-272. Pathophysiology. Benefits of L-carnitine. Weigel, C., Kiener, C., Meier, N., Schmid, P., Rauh, M., Rascher, W., and Knerr, I. Carnitine status in early-treated children, adolescents and young adults with phenylketonuria on low phenylalanine diets. Gynecol Endocrinol 2019;35(8):701-5. doi: 10.1080/09513590.2019.1576622. View abstract. Endocr Metab Immune Disord Drug Targets 2020. L-Carnitine is a naturally occurring substance that the body needs for energy. View abstract. View abstract. View abstract. View abstract. 2008;46(2):181-190. The effects of L-carnitine supplementation on performance during interval swimming. Clin Mol Hepatol. Hemodial.Int. Andrologia. Last updated on Aug 31, 2022. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. View abstract. View abstract. View abstract. Int.J Cardiol. Cochrane.Database.Syst.Rev. Use of a long-chain triglyceride-restricted/medium-chain triglyceride-supplemented diet in a case of malonyl-CoA decarboxylase deficiency with cardiomyopathy. Mantovani G, Maccio A, Madeddu C, et al. Med.Sci Monit. Bartels GL, Remme WJ, Holwerda KJ, Kruijssen DA. 3. Does L carnitine coffee make you lose weight? Improved excercise tolerance after administration of carnitine. Med.Sci Monit. 2010;16(10):919-921. Faria, C. C., Mota, J. F., Paula Ravagnani, F. C., and Burini, R. C. [The supplementation of L-carnitine does not promote alterations in the resting metabolic rate and in the use of energetic substrates in physically active individuals]. Lion's mane mushrooms may offer a number of health benefits. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Obstet.Gynecol. Tempesta E, Casella L, Pirrongelli C, et al. Int J Fertil 1977;22:85-91. Socha, P., Horvath, A., Vajro, P., Dziechciarz, P., Dhawan, A., and Szajewska, H. Pharmacological interventions for nonalcoholic fatty liver disease in adults and in children: a systematic review. J Clin Biochem.Nutr. View abstract. J Neuropsychiatry Clin Neurosci. BMC Musculoskelet Disord 2021;22(1):195. Rajasekar, P. and Anuradha, C. V. Effect of L-carnitine on skeletal muscle lipids and oxidative stress in rats fed high-fructose diet. Carnitine deficiency disorders in children. View abstract. View abstract. View abstract. View abstract. However, you should always pick the form thats best for your personal needs and goals. View abstract. View abstract. View abstract. View abstract. Reduce dosage to alleviate this side effect. Effects of L-carnitine supplemented total parenteral nutrition on lipid and energy metabolism in postoperative stress. Shapira Y, Gutman A. J Ren Nutr 1998;8:118-21. View abstract. J Clin Endocrinol Metab. Genazzani, A. D., Lanzoni, C., Ricchieri, F., Santagni, S., Rattighieri, E., Chierchia, E., Monteleone, P., and Jasonni, V. M. Acetyl-L-carnitine (ALC) administration positively affects reproductive axis in hypogonadotropic women with functional hypothalamic amenorrhea. View abstract. Krahenbuhl S. Carnitine metabolism in chronic liver disease. All rights reserved. These bacteria digest L-carnitine and turn it into a compound called trimethylamine-N-oxide (TMAO). View abstract. For your body to produce it in sufficient amounts, you also need plenty of vitamin C (4). Insomnia (unable to sleep). 1992;141(11):379-384. J Pediatr 1982;101:782-5. View abstract. Basic Clin Pharmacol Toxicol. Cuturic, M., Abramson, R. K., Moran, R. R., and Hardin, J. W. Clinical outcomes and low-dose levocarnitine supplementation in psychiatric inpatients with documented hypocarnitinemia: a retrospective chart review. Lster H, Miehe K, Punzel M, et al. L-Carnosine Dosage. Pediatr.Res. Ma, S. J., Cai, W. W., and Sheng, J. Miyagawa T, Kawamura H, Obuchi M, Ikesaki A, Ozaki A, Tokunaga K, Inoue Y, Honda M. Effects of oral L-carnitine administration in narcolepsy patients: a randomized, double-blind, cross-over and placebo-controlled trial. Xie, H., Tang, S. Y., Li, H., Luo, X. H., Yuan, L. Q., Wang, D., and Liao, E. Y. L-carnitine protects against apoptosis of murine MC3T3-E1 osteoblastic cells. View abstract. Nephron 1991;57(3):306-313. de Lira-Garcia, C., Souto-Gallardo, M., Bacardi-Gascon, M., and Jimenez-Cruz, A. 10-21-2011;17(39):4414-4420. 2018 Oct;59(10):2360-2368. L-Carnitine treatment reduces severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical trial. Am J Clin Nutr 2007;86:1738-44. J Cardiovasc.Pharmacol 2007;50(2):168-175. Nutr Metab Cardiovasc.Dis. Effects of L-carnitine supplementation on lipid profiles in patients with coronary artery disease. Biol Neonate 1990;58:81-8. J Pain Symptom Manage 2006;32:551-9. Block, K. I., Koch, A. C., Mead, M. N., Tothy, P. K., Newman, R. A., and Gyllenhaal, C. Impact of antioxidant supplementation on chemotherapeutic toxicity: a systematic review of the evidence from randomized controlled trials. L-carnitine decreases severity and type of fatigue induced by interferon-alpha in the treatment of patients with hepatitis C. Neuropsychobiology 2003;47:94-7. . 1987;24(1):23-28. I noticed very sensitive teeth and gums for awhile, but seems to have . Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. 2010;25(8):954-960. (56-58) L-carnitine levels may be decreased in hypothyroidism, potentially due to reduced synthesis of L-carnitine while we are in a . View abstract. Gentile, V., Antonini, G., Antonella, Bertozzi M., Dinelli, N., Rizzo, C., Ashraf, Virmani M., and Koverech, A. Ren Fail. View abstract. View abstract. Dragan, A. M., Vasiliu, D., Eremia, N. M., and Georgescu, E. Studies concerning some acute biological changes after endovenous administration of 1 g l-carnitine, in elite athletes. A few people may notice mild headaches. View abstract. Arch.Pediatr. Prostaglandins Leukot.Essent.Fatty Acids 2002;67(1):33-38. Neurochem.Res. 2010;38:152-5. 2020;37:9-23. View abstract. However, this does not explain why insomnia actually occurs. Effect of 8-day therapy with propionyl-L-carnitine on muscular and subcutaneous blood flow of the lower limbs in patients with peripheral arterial disease. A. 2010;105(6):1338-1345. J Inherit.Metab Dis 2008;31(3):361-367. J Clin Endocrinol Metab 2001;86:3579-94. It can cause nausea, abdominal cramps, vomiting, and diarrhea when taken in high doses. Effects of L- and DL-carnitine on patients with impaired exercise tolerance. 2009;10(12):1875-1882. View abstract. The effect of L-carnitine on insulin resistance in hemodialysed patients with chronic renal failure. View abstract. View abstract. Castro-Gago M, Eiris-Punal J, Novo-Rodriguez MI, et al. 2011;13(5):392-395. Epilepsia 1998;39:1216-25. Effects of carnitine supplementation on flow-mediated dilation and vascular inflammatory responses to a high-fat meal in healthy young adults. Pettegrew JW, Klunk WE, Panchalingam K, et al. Circulation 1988;77:767-73. Miles, C. L., Candy, B., Jones, L., Williams, R., Tookman, A., and King, M. Interventions for sexual dysfunction following treatments for cancer. View abstract. You can improve your brain health with the right diet. View abstract. More research is needed on long-term benefits for healthy individuals. 2007;16 Suppl 1:383-390. Jirillo, E., Altamura, M., Munno, I., Pellegrino, N. M., Sabato, R., Di Fabio, S., and De Simone, C. Effects of acetyl-L-carnitine oral administration on lymphocyte antibacterial activity and TNF-alpha levels in patients with active pulmonary tuberculosis. Effects of Citric Acid and l-Carnitine on Physical Fatigue. View abstract. View abstract. Kubota K, Uojima H, Shao X, et al. Rossini, M., Di, Munno O., Valentini, G., Bianchi, G., Biasi, G., Cacace, E., Malesci, D., La, Montagna G., Viapiana, O., and Adami, S. Double-blind, multicenter trial comparing acetyl l-carnitine with placebo in the treatment of fibromyalgia patients. 2007;29(8):517-530. Zhonghua Nan.Ke.Xue. It helps transport fatty acids into the mitochondria where they can be burned up and used as fuel. Sima AAF, Calvani M, Mehra M, et al. Taking your CoQ10 with food not only helps . View abstract. Int.Angiol. View abstract. View abstract. View abstract. Int J Clin Pharmacol Res 1988;8(5):367-376. Am J Dis Child 1991;145:999-1001. 2007;62(4):349-354. Carnitine versus androgen administration in the treatment of sexual dysfunction, depressed mood, and fatigue associated with male aging. View abstract. View abstract. This may lead to irritability, hyperactivity or insomnia. View abstract. Caruso U, Cravotto E, Tisone G, and et al. View abstract. The early effects of intravenous L-propionyl carnitine on ulcerative trophic lesions of the lower limbs in arteriopathic patients: a controlled randomized study. Hepatol. Drugs Exp Clin Res 1999;25:29-36. Nefrologia. 2011;(12):CD006282. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Shingu Y, Katoh N, Ooka T, Katoh H, Wakasa S. L-Carnitine supplementation for the prevention of postoperative atrial fibrillation in aortic valve surgery. Nourshahi, M., Rajaeyan, A., Kimiagar, M., and Ebrahim, K. The effects of L-carnitine supplementation in different phases of menstrual cycle on the metabolic responses after exhausted exercise in active women. J Peripher Nerv Syst 1997;2:250-2. View abstract. Pediatr.Hematol.Oncol. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. 1994;60(12):707-713. 2010;45(6):762-763. View abstract. J Inherit.Metab Dis 9-10-2010; View abstract. Mar.Drugs 2009;7(1):57-70. View abstract. Nasser, M., Javaheri, H., Fedorowicz, Z., and Noorani, Z. Carnitine supplementation for inborn errors of metabolism. 2007;26(1):93-94. J Neurol.Sci 3-15-2004;218(1-2):103-108. L-Carnosine (Fig. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to levocarnitine: injectable solution, oral capsule, oral solution, oral tablet. A., Flory, J., Rowan, C. G., and Brunelli, S. M. Effects of L-carnitine on dialysis-related hypotension and muscle cramps: a meta-analysis. View abstract. Clin Lymphoma Myeloma Leuk. 2009;19(3):212-216. View abstract. Comparison of pharmacokinetics of L-carnitine, acetyl-L-carnitine and propionyl-L-carnitine after single oral administration of L-carnitine in healthy volunteers. 2011;55(8):1022-1028. Csiky, B., Nyul, Z., Toth, G., Wittmann, I., Melegh, B., Rauh, M., Rascher, W., and Sulyok, E. L-carnitine supplementation and adipokines in patients with end-stage renal disease on regular hemodialysis. Levocarnitine administration in multiple sclerosis patients with immunosuppressive therapy-induced fatigue. J.Japanese Society Nutrition Food Sci 2007;60(5):257-264. J Physiol Biochem. J Am Coll Cardiol 1995;26:1411-6. Acetyl-L-carnitine (ALC) is a form of amino-acid carnitine, used as a dietary supplement and nootropic. 2020;52(2):e13470. View abstract. Toptas, B., Baykal, A., Yesilipek, A., Isbir, M., Kupesiz, A., Yalcin, O., and Baskurt, O. K. L-carnitine deficiency and red blood cell mechanical impairment in beta-thalassemia major. Mingrone G. Carnitine in type 2 diabetes. The role of carnitine supplementation during valproic acid therapy. Supplements may also benefit those with lower levels, such as older adults, vegans and vegetarians. View abstract. Perna, A. F., Acanfora, F., Satta, E., Lombardi, C., Capasso, R., Ingrosso, D., and De Santo, N. G. L-Propionyl carnitine, homocysteine and S-adenosylhomocysteine in hemodialysis. Huang H, Song L, Zhang H, Zhang H, Zhang J, Zhao W. Influence of L-carnitine supplementation on serum lipid profile in hemodialysis patients: a systematic review and meta-analysis. Anon. It can cause side effects such as stomach upset, heartburn, diarrhea, and seizures. El Beshlawy, A., Mohtar, G., Abd El, Ghafar E., Abd El Dayem, S. M., El Sayed, M. H., Aly, A. Even though the chance of adverse side effects is slight, there are two things that we suggest when taking Coenzyme Q10. Nausea and vomiting Diarrhea Other possible side effects may include: Headaches and dizziness Insomnia Fatigue Skin itching or rashes Irritability or agitation The safety of use of CoQ10 during pregnancy and breast-feeding hasn't been established. Effects of L-carnitine on exercise tolerance in chronic stable angina: a multicenter, double-blind, randomized, placebo-controlled, crossover study. View abstract. Ciacci C, Peluso G, Iannoni E, et al. B., Karall, D., de, Klerk H., Knerr, I., Koch, H. G., Plecko, B., Roschinger, W., Schwab, K. O., Scheible, D., Wijburg, F. A., Zschocke, J., Mayatepek, E., and Wendel, U. View abstract. Maggi GC, Lomanto B, and Mazzola, C. Double-blind multicenter clinical trial on the efficacy of phosphocreatinine vs L-carnitine and placebo in a group of patients affected by heart disease. View abstract. Cochrane.Database.Syst.Rev. B. View abstract. Carroll, J. K., Kohli, S., Mustian, K. M., Roscoe, J. In studies in mice, TMAO has been shown to cause atherosclerosis, the disease process that leads . Jung, J., Eo, E., and Ahn, K. O. Nephron 55 (1990): 28-32. View abstract. Malaguarnera, M., Vacante, M., Bertino, G., Neri, S., Malaguarnera, M., Gargante, M. P., Motta, M., Lupo, L., Chisari, G., Bruno, C. M., Pennisi, G., and Bella, R. The supplementation of acetyl-L-carnitine decreases fatigue and increases quality of life in patients with hepatitis C treated with pegylated interferon-alpha 2b plus ribavirin. L-carnitine has most often been used by adults in doses of 2 grams by mouth daily. Neurological: headaches, dizziness. Three-year survival of patients with heart failure caused by dilated cardiomyopathy and L-carnitine administration. Anemia and carnitine supplementation in hemodialyzed patients. A., Kraemer, W. J., Hatfield, D. L., Vingren, J. L., Fragala, M. S., Ho, J. Y., Thomas, G. A., Hakkinen, K., and Volek, J. S. Effects of L-carnitine L-tartrate supplementation on muscle oxygenation responses to resistance exercise. 2011;31(2):125-132. This form exhibited similar benefits for general brain function in older adults who did not have Alzheimers or other brain conditions (35, 36, 37). However, L-carnitine supplements may raise your blood levels of trimethylamine-N-oxide (TMAO) over time. Muscle carnitine deficiency: adult onset lipid storage myopathy with sensory neuropathy. Hypertension 2010;55(2):e13. Asymptomatic hyperammonemia in children treated with valproic acid. Minerva Urol.Nefrol. Penn, D., Schmidt-Sommerfeld, E., and Pascu, F. Decreased tissue carnitine concentrations in newborn infants receiving total parenteral nutrition. Baghban F, Hosseinzadeh M, Mozaffari-Khosravi H, Dehghan A, Fallahzadeh H. The effect of L-Carnitine supplementation on clinical symptoms, C-reactive protein and malondialdehyde in obese women with knee osteoarthritis: a double blind randomized controlled trial. Curr Ther Res 1980;27(2):208-216. Rausch CR, Paul S, Marx KR, et al. Yet, there are a few known side effects that include agitation, insomnia and nausea. Carnosine is found throughout your body. View abstract. Pola, P., Tondi, P., Flore, R., Serricchio, M., Dal Lago, A., Amanti, C., Consorti, F., Benedetti, M., and Midiri, H. Effect of l-carnitine on lipid pattern in debilitated patients treated with Intralipid. View abstract. View abstract. Clin Ther 2012;34(8):1674-1682. Rebuzzi AG, Schiavani G, Amico C, and et al. More research is needed to confirm the benefits of L-carnitine in a younger, more active population. Rossini, D., Bulckaen, M., Di, Marco S., Giovannetti, R., Giuntoli, F., Lacopetti, L., and Vergoni, W. [Rehabilitation program in patients with moderate-to-severe intermittent claudication: immediate results and one year follow-up]. Biol.Trace Elem.Res 2012;150(1-3):42-48. Anxiety (feeling nervous and jittery). Long-term acetyl-L-carnitine treatment in Alzheimer's Disease. View abstract. Malaguarnera, M., Vacante, M., Motta, M., Malaguarnera, M., Li, Volti G., and Galvano, F. Effect of L-carnitine on the size of low-density lipoprotein particles in type 2 diabetes mellitus patients treated with simvastatin. A randomized, double-blind, placebo-controlled trial of L-carnitine in suspected acute myocardial infarction. View abstract. Invest Clin 2007;48(2):243-248. Drugs Exp Clin Res 1987;13:417-23. Although potent on its own, this supplement works best when stacked with other nootropics. Signorelli, S. S., Fatuzzo, P., Rapisarda, F., Neri, S., Ferrante, M., Oliveri, Conti G., Fallico, R., Di, Pino L., Pennisi, G., Celotta, G., and Massimiliano, A. View abstract. Am J Cardiol. Sheida A, Davar R, Tabibnejad N, Eftekhar M. The effect of adding L-Carnitine to the GnRH-antagonist protocol on assisted reproductive technology outcome in women with polycystic ovarian syndrome: a randomized clinical trial. 2018 Jun;20(3):285-290. View abstract. Eur.J.Gen.Med 2009;6(2):7-15. View abstract. Zhonghua Xin.Xue.Guan.Bing.Za Zhi. Cao, Y., Wang, Y. X., Liu, C. J., Wang, L. X., Han, Z. W., and Wang, C. B. L-carnitine supplementation vs cycle ergometer exercise for physical activity and muscle status in hemodialysis patients: a randomized clinical trial. Even higher doses may cause insomnia. Eur Heart J 1992;13:251-5. Gurlek, A., Tutar, E., Akcil, E., Dincer, I., Erol, C., Kocaturk, P. A., and Oral, D. The effects of L-carnitine treatment on left ventricular function and erythrocyte superoxide dismutase activity in patients with ischemic cardiomyopathy. Mantovani, G., Maccio, A., Madeddu, C., Gramignano, G., Serpe, R., Massa, E., Dessi, M., Tanca, F. M., Sanna, E., Deiana, L., Panzone, F., Contu, P., and Floris, C. Randomized phase III clinical trial of five different arms of treatment for patients with cancer cachexia: interim results. You may report side effects to FDA at 1-800-FDA-1088. Support Care Cancer. View abstract. 2011;270(1):76-84. Laforet, P. and Vianey-Saban, C. Disorders of muscle lipid metabolism: diagnostic and therapeutic challenges. Along with its needed effects, levocarnitine (the active ingredient contained in L-Carnitine) may cause some unwanted effects. Sigma-Tau Pharmaceuticals Inc, Gaithersburg, MD. 2010;16(3):235-249. Sarafoglou, K., Tridgell, A. H., Bentler, K., Redlinger-Grosse, K., Berry, S. A., and Schimmenti, L. A. Cardiac conduction improvement in two heterozygotes for primary carnitine deficiency on L-carnitine supplementation. View abstract. Effect of carni Q-gel (ubiquinol and carnitine) on cytokines in patients with heart failure in the Tishcon study. A multicentre, randomized, parallel, placebo-controlled trial. Oral carnitine supplementation reduces body weight and insulin resistance in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Serban MC, Sahebkar A, Mikhailidis DP, et al. 2007;18(3):169-176. Interestingly, food sources of L-carnitine have a greater absorption rate than supplements. Heringer, J., Boy, S. P., Ensenauer, R., Assmann, B., Zschocke, J., Harting, I., Lucke, T., Maier, E. M., Muhlhausen, C., Haege, G., Hoffmann, G. F., Burgard, P., and Kolker, S. Use of guidelines improves the neurological outcome in glutaric aciduria type I. Ann.Neurol. Casciani, C. U., Caruso, U., Cravotto, E., Corsi, M., Pola, P., Savi, L., and Grilli, M. Effect of L-carnitine on lipid pattern in haemodialysis. 2008;23(7):1602-1606. 2010;16(1):5-14. View abstract. Effect of L-carnitine supplement on semen parameters in men with idiopathic infertility. Urology 2004;63:641-6. View abstract. Nausea and Vomiting The Linus Pauling Institute notes that common side effects of taking L-carnitine supplements are nausea and vomiting 1. Z., and McIntyre, R. S. Acetyl-L-carnitine and alpha-lipoic acid: possible neurotherapeutic agents for mood disorders? View abstract. Tell your doctor if you are pregnant or plan to become pregnant. 11-15-2008;102(10):1413-1417. . Drugs Exp Clin Res 1995;21(4):157-159. Note: This document contains side effect information about levocarnitine. View abstract. Effects of wuzi yanzong liquids combing with L-carnitine on oligospermia and asthenospermia. Dig.Dis Sci 2006;51(3):488-494. Can L-carnitine supplementation and exercise improve muscle complications in patients with liver cirrhosis who receive branched-chain amino acid supplementation? Acta Europ Fertil 1992;23:221-4. Cell Death.Dis 2010;1:e62. View abstract. Current Therapeutic Research 1986;39(3):429-435. Eur.J Clin.Nutr. Antioxidant treatment with carnitines is effective in infertile patients with prostatovesiculoepididymitis and elevated seminal leukocyte concentrations after treatment with nonsteroidal anti-inflammatory compounds. It plays a crucial role in the production of energy by transporting fatty acids into your cells mitochondria (1, 2, 3). 2006;8(5 Pt 1):503-507. Andrologia 1994;26(3):155-159. Int.Clin Psychopharmacol. View abstract. Yano J, Kaida Y, Maeda T, et al. Kosolcharoen T, Nappi J, Peduzzi P, and et al. View abstract. Int.J Vitam.Nutr.Res. Laker MF, Green C, Bhuiyan AK, Shuster S. Isotretinoin and serum lipids: studies on fatty acid, apolipoprotein and intermediary metabolism. Sweets. 2009;47(9):748-753. Zhongguo Dang.Dai Er.Ke.Za Zhi. 2007;21(1):259-264. Jacobs, P. L. and Goldstein, E. R. Long-term glycine propionyl-l-carnitine supplemention and paradoxical effects on repeated anaerobic sprint performance. Plasma and urine carnitine concentrations in well-trained athletes at rest and after exercise. Leuk Lymphoma. View abstract. Infusionsther.Klin.Ernahr. View abstract. View abstract. 2011;17(7):H55-H59. Acute effect on satiety, resting energy expenditure, respiratory quotient, glucagon-like peptide-1, free fatty acids, and glycerol following consumption of a combination of bioactive food ingredients in overweight subjects. Diabetologia 1997;40(1):A32. Lancet 1989;2:469-73. Pharmacol Rev 2002;54:589-98. View abstract. It seemed to get me fairly wired. View abstract. View abstract. Nihon Rinsho 2007;65(6):1005-1010. Some animal studies suggest that the acetyl form, acetyl-L-carnitine (ALCAR), may help prevent age-related mental decline and improve markers of learning (30, 31). Golper, T. A., Wolfson, M., Ahmad, S., Hirschberg, R., Kurtin, P., Katz, L. A., Nicora, R., Ashbrook, D., and Kopple, J. D. Multicenter trial of L-carnitine in maintenance hemodialysis patients. Plioplys AV, Kasnicka I. L-carnitine as a treatment for Rett syndrome. Eroglu, H., Senel, O., and Guzel, N. A. View abstract. 2000;10(5):247-251. Clin Trials J 1990;27:155-163. Side Effects. View abstract. View abstract. 2007;110(2 Pt 2):480-482. Randomized phase III clinical trial of five different arms of treatment in 322 patients with cancer cachexia. Effect of L-carnitine treatment in vivo on apoptosis and ceramide generation in peripheral blood lymphocytes from AIDS patients. A., Servan-Schreiber, D., Panchalingam, K., and McClure, R. J. A., Bromberg, M. B., Chan, G. M., and Kissel, J. T. SMA CARNI-VAL trial part I: double-blind, randomized, placebo-controlled trial of L-carnitine and valproic acid in spinal muscular atrophy. J Mol.Histol. View abstract. View abstract. Rajasekar, P., Palanisamy, N., and Anuradha, C. V. Increase in nitric oxide and reductions in blood pressure, protein kinase C beta II and oxidative stress by L-carnitine: a study in the fructose-fed hypertensive rat. View abstract. Lai CL, Ahn SH, Lee KS, Um SH, Cho M, Yoon SK, Lee JW, Park NH, Kweon YO, Sohn JH, Lee J, Kim JA, Han KH, Yuen MF. Corsi, C., Pollastri, M., Marrapodi, E., Leanza, D., Giordano, S., and D'Iddio, S. L-propionylcarnitine effect on postexercise and postischemic hyperemia in patients affected by peripheral vascular disease. Brevetti G, Perna S, Sabba C, et al. High doses of L-carnitine in acute myocardial infarction: metabolic and antiarrhythmic effects. Cai, T., Wagenlehner, F. M., Mazzoli, S., Meacci, F., Mondaini, N., Nesi, G., Tiscione, D., Malossini, G., and Bartoletti, R. Semen quality in patients with Chlamydia trachomatis genital infection treated concurrently with prulifloxacin and a phytotherapeutic agent. Tarighat, Esfanjani A., Mahdavi, R., Ebrahimi, Mameghani M., Talebi, M., Nikniaz, Z., and Safaiyan, A. Cochrane.Database.Syst.Rev. View abstract. View abstract. Gynecol Endocrinol 2018;34(8):684-8. Vidal-Casariego A, Burgos-Pelez R, Martnez-Faedo C, Calvo-Gracia F, Valero-Zanuy M, Luengo-Prez LM, Cuerda-Comps C. Metabolic effects of L-carnitine on type 2 diabetes mellitus: systematic review and meta-analysis. Brass, E. P., Adler, S., Sietsema, K. E., Hiatt, W. R., Orlando, A. M., and Amato, A. J.HainanMed.College 2011;17(3):347-349. 2007;45(7):513-517. View abstract. Liu J, Head E, Kuratsune H, et al. Shakeri, A., Tabibi, H., and Hedayati, M. Effects of L-carnitine supplement on serum inflammatory cytokines, C-reactive protein, lipoprotein (a), and oxidative stress in hemodialysis patients with Lp (a) hyperlipoproteinemia. Novel mutation of methylmalonyl-CoA mutase gene in a Thai infant with methylmalonic acidemia (mut0). Hiatt, W. R., Creager, M. A., Amato, A., and Brass, E. P. Effect of propionyl-L-carnitine on a background of monitored exercise in patients with claudication secondary to peripheral artery disease. View abstract. The effect of combined L-carnitine and erythropoietin administration on the anaemia and on the lipid profile of patients on hemodialysis [abstract]. It can also cause the urine, breath, and sweat to have a "fishy" odor. Am J Kidney Dis. View abstract. 11. In a preliminary analysis, we reported that L-carnitine could improve fatigue, mood and sleep. View abstract. 2010;5(8):e12140. Effects of L-carnitine supplementation on physical performance and energy metabolism of endurance-trained athletes: a double-blind crossover field study. Micic S, Lalic N, Djordjevic D, et al. Evaluation of the effects of L-acetylcarnitine on senile patients suffering from depression. Preventive effect of L-carnitine on scar formation during acute pyelonephritis: A randomized placebo-controlled trial.